Beneficial effects of soybean isoflavone supplementation on bone metabolism and serum lipids in postmenopausal Japanese women: A four-week study
Beneficial effects of soybean isoflavone supplementation on bone metabolism and serum lipids in postmenopausal Japanese women: A four-week study
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DOI：
10.1080/07315724.2002.10719200
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发表时间：
2002-04-01
影响因子：
3.5
通讯作者：
Yamori, Y
中科院分区：
文献类型：
--
作者：
Uesugi, T;Fukui, Y;Yamori, Y
目的：本研究的目的是确定大豆异黄酮与弱雌激素样活性对骨代谢和血脂在围绝经期women.Methods：23名健康围绝经期妇女随机分配到无论是雌激素或安慰剂组的影响。试验组（n = 12）每天接受大豆提取物胶囊（61.8 mg的大豆黄酮），安慰剂组（n = 11）每天接受安慰剂胶囊，持续四周。在第0周、第2周和第4周测量尿液中的排泄量。结果：与安慰剂组相比，治疗组第2周和第4周尿吡啶啉和脱氧吡啶啉排泄量、骨硬度、血清胆固醇、甘油三酯和胆固醇水平均增加。骨吸收标志物的排泄在骨吸收组中显著减少。血清总胆固醇和低密度脂蛋白胆固醇均显著降低。其他血清生化参数没有改变，在任何group.Conclusion：大豆蛋白补充四周显示出潜在的有益影响，对骨代谢和血脂在围绝经期妇女。这些作用可能有可能降低这些妇女绝经后骨质疏松症和心血管疾病的风险。
Objective: The aim of this study was to determine the effects of soy isoflavones with weak estrogen-like activities both on bone metabolism and on serum lipids in perimenopausal women.Methods: Twenty-three healthy perimenopausal women were assigned randomly to either isoflavone or placebo groups. The isoflavone group (n = 12) received daily capsules of soy isoflavone extract (61.8 mg of isoflavones) and the placebo group (n = 11) received daily placebo capsules for four weeks. Urinary excretion of isoflavone was measured at weeks 0, 2 and 4. Urinary excretion of pyridinoline and deoxypyridinoline, bone stiffness and levels of serum cholesterol, triglyceride and cholesterol fractions were measured at weeks 0 and 4.Results: As compared to the placebo group, urinary isoflavone, primarily daidzein, excretion was increased at weeks 2 and 4 in the isoflavone group. Excretion of bone resorption markers was reduced significantly in the isoflavone group. Both total serum cholesterol and LDL cholesterol were decreased significantly in the isoflavone group. Other serum biochemical parameters were not changed in either group.Conclusion: Soy isoflavone supplementation for four weeks showed potentially beneficial effects on bone metabolism and on serum lipids in perimenopausal women. These effects could have the potential to reduce the risks of postmenopausal osteoporosis and of cardiovascular diseases in such women.