Prenatal Stress Exposure Related to Maternal Bereavement and Risk of Childhood Overweight
Prenatal Stress Exposure Related to Maternal Bereavement and Risk of Childhood Overweight
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DOI：
10.1371/journal.pone.0011896
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发表时间：
2010-07-30
期刊：
影响因子：
3.7
通讯作者：
Sorensen, Thorkild I. A.
中科院分区：
文献类型：
--
作者：
Li, Jiong;Olsen, Jorn;Sorensen, Thorkild I. A.
背景：有研究表明，产前压力会增加日后患肥胖症的风险。在一项以人群为基础的队列研究中，我们研究了是否产前压力与孕产妇丧亲在怀孕期间与超重的风险在后代在学龄。方法/主要调查结果：我们遵循了65,212名儿童出生在丹麦从1970年至1989年谁进行了健康检查，从7至13岁的公立或私立学校在哥本哈根。我们确定了459名儿童暴露于产前压力，定义为从怀孕前一年直到孩子出生，母亲因近亲死亡而失去亲人。我们比较了暴露者和未暴露者的超重患病率。与未受辐射儿童相比，受辐射儿童的体重指数（BMI）值和超重发生率较高，但直到10岁及以上才有显著差异。例如，12岁时超重的校正比值比（OR）为1.68（95%置信区间[CI] 1.08-2.61），13岁时为1.63（95% CI 1.00-2.61）。妊娠前6 ~ 0个月死亡的OR值最高（12岁时OR 3.31，95% CI 1.71-6.42，13岁时OR 2.31，95% CI 1.08-4.97）。我们的研究结果表明，严重的孕前压力与后代在童年后期超重的风险增加有关。
Background: It has been suggested that prenatal stress contributes to the risk of obesity later in life. In a population-based cohort study, we examined whether prenatal stress related to maternal bereavement during pregnancy was associated with the risk of overweight in offspring during school age.Methodology/Principal Findings: We followed 65,212 children born in Denmark from 1970-1989 who underwent health examinations from 7 to 13 years of age in public or private schools in Copenhagen. We identified 459 children as exposed to prenatal stress, defined by being born to mothers who were bereaved by death of a close family member from one year before pregnancy until birth of the child. We compared the prevalence of overweight between the exposed and the unexposed. Body mass index (BMI) values and prevalence of overweight were higher in the exposed children, but not significantly so until from 10 years of age and onwards, as compared with the unexposed children. For example, the adjusted odds ratio (OR) for overweight was 1.68 (95% confidence interval [CI] 1.08-2.61) at 12 years of age and 1.63 (95% CI 1.00-2.61) at 13 years of age. The highest ORs were observed when the death occurred in the period from 6 to 0 month before pregnancy (OR 3.31, 95% CI 1.71-6.42 at age 12, and OR 2.31, 95% CI 1.08-4.97 at age 13).Conclusions/Significance: Our results suggest that severe pre-pregnancy stress is associated with an increased risk of overweight in the offspring in later childhood.