Treatment with alpha interferon associated with the development of paraneoplastic pemphigus.
Treatment with alpha interferon associated with the development of paraneoplastic pemphigus.
复制标题
与副肿瘤性天疱疮的发展相关的α干扰素治疗。
DOI：
10.1111/j.1365-2133.1995.tb08688.x
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Kerdel,FA
中科院分区：
文献类型：
--
作者：
Kirsner,RS;Anhalt,GJ;Kerdel,FA
干扰素的使用通常被认为是安全的，主要的副作用是流感样综合征。然而，由于其能够改变免疫应答，干扰素与自身免疫性疾病的诱导有关。我们报告一例沃尔登斯特伦巨球蛋白血症患者，在全身应用干扰素-α2A(干扰素)治疗多发性皮肤癌后出现全身水泡皮疹。患者皮肤表现为副肿瘤性天疱疮的组织学特征、免疫荧光表现和免疫沉淀诊断。尽管进行了积极的治疗，患者还是死亡了。在我们的患者中，干扰素的使用与副肿瘤性天疱疮的发展是暂时相关的。尽管干扰素已被证明可引发其他自身免疫性疾病，但据我们所知，这只是第二例使用干扰素治疗的患者随后患上致命的自身免疫性水泡疾病的报告。副肿瘤性天疱疮是最近被描述的一种自身免疫性大疱性疾病，预后不良。干扰素触发副肿瘤性天疱疮的机制尚不清楚。
The use of interferon (INF) is usually considered safe, the major side‐effect being a flu‐like syndrome. However, with its ability to alter immune responsiveness, INF has been associated with the induction of autoimmune diseases.We report a patient with Waldenström's macroglobulinaemia who developed a generalized blistering eruption after treatment with systemic INF‐α 2A (INF) for multiple skin cancers. The patient's skin showed histological features, immunofluorescence findings, and immunoprecipitation diagnostic of paraneoplastic pemphigus. Despite aggressive treatment the patient died.In our patient, the use of INF was temporally related to the development of paraneoplastic pemphigus. Although interferon has been shown to induce other autoimmune diseases, to our knowledge this is only the second report of a patient treated with an interferon who subsequently developed a fatal autoimmune blistering disorder. Paraneoplastic pemphigus is a recently described autoimmune bullous disorder with a poor prognosis. The mechanism by which INF triggered the paraneoplastic pemphigus is not known.