Oxidative Stress and Executive Function in Children Receiving Chemotherapy for Acute Lymphoblastic Leukemia
Oxidative Stress and Executive Function in Children Receiving Chemotherapy for Acute Lymphoblastic Leukemia
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DOI：
10.1002/pbc.22128
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发表时间：
2009-10-01
影响因子：
3.2
通讯作者：
Moore, Ida M.
中科院分区：
文献类型：
--
作者：
Caron, Joshua E.;Krull, Kevin R.;Moore, Ida M.
背景。据报道，很大比例的儿童急性淋巴细胞白血病（ALL）治疗后出现神经认知后遗症，包括仅接受化疗的患者。早期识别“有神经认知问题风险”的儿童尚不可靠。脑脊液 (CSF) 中的氧化应激生物标志物（例如氧化磷脂酰胆碱）与甲氨蝶呤 (MTX) 治疗强度相关，表明与急性中枢神经系统毒性相关。程序。这项研究检查了氧化脑脊液磷脂与整个化疗过程中执行功能之间的关联。对 88 名新诊断患有 ALL 的儿童进行了氧化应激和执行功能测量。对这些孩子进行了三年多的神经认知测试和家长对执行功能的评分。结果。结果表明，诱导和巩固后氧化应激增加与两年后执行功能下降之间存在关联。诊断时年龄较小与氧化应激和执行功能障碍的增加有关；年龄较小与在环境中组织材料的能力较差相关（r(48)=0.28，P
Background. Neurocognitive sequelae following treatment for pediatric acute lymphoblastic leukemia (ALL) has been reported in a significant proportion Of Survivors, including those treated only with chemotherapy. Early identification of children "at risk" for neurocognitive problems is not yet reliable. Biomarkers of oxidative stress (e.g., oxidated phosphatidylcholine) in cerebral spinal fluid (CSF) have been correlated with intensity of methotrexate (MTX) treatment, Suggesting an association with acute central nervous system toxicity. Procedure. This study examined the association between oxidized CSF phospholipids and executive functions throughout chemotherapy. Measures of oxidative stress and execotive functions were examined in 88 children newly diagnosed with ALL. The children were followed over 3 years with neurocognitive testing and parent ratings of executive functions. Results. Results demonstrated an association between increased oxidative stress following induction and consolidation and decreased executive function 2 years later. Younger age at diagnosis was associated with both an increase in oxidative stress and in executive dysfunction; Younger age was associated with poorer ability to organize materials in one's environment (r(48)=0.28, P