Idiotypic regulation in immune networks.
Idiotypic regulation in immune networks.
复制标题
免疫网络中的独特型调节。
DOI：
10.1007/978-1-4684-3917-5_4
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
P. Cazenave
中科院分区：
文献类型：
--
作者：
Jacques Urbain;C. Wuilmart;P. Cazenave
For almost twenty years now, the clonal selection theory (Jerne, 1955; Burnet, 1959; Lederberg, 1959) has been the major paradigm for most immunologists. The clonal selection theory has a great appeal to logic and the elegance of simplicity, and it is in fact able to account for a vast body of data. The central idea of clonal selection is that the immune system is a library of precommitted clones, able to manufacture a pair of V-region polypeptides (VH and VL). It is essential to the clonal selection theory that each member of the clone expresses the same pair of V genes.
