Thioredoxins and related proteins in photosynthetic organisms: molecular basis for thiol dependent regulation
Thioredoxins and related proteins in photosynthetic organisms: molecular basis for thiol dependent regulation
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DOI：
10.1016/s0006-2952(02)01177-2
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发表时间：
2002-09-01
影响因子：
5.8
通讯作者：
Aubry, A
中科院分区：
文献类型：
--
作者：
Jacquot, JP;Gelhaye, E;Aubry, A
硫氧还蛋白是一种小分子量二硫键氧化还原酶，专门用于还原其他蛋白质上的二硫键。一般来说，被这些蛋白质选择性和可逆地还原的酶在氧化的和不活跃的构象和还原和活跃的构象之间振荡。硫氧还蛋白是由谷氧还蛋白和蛋白二硫键异构酶组成的蛋白二硫键氧化还原酶家族的原型。硫氧还蛋白和谷氧还蛋白在细胞中发挥多种作用，包括对靶酶和转录因子的氧化还原调节。它们还可以作为过氧化还蛋白的供氢者，过氧化还蛋白是最近发现的无血红素过氧化物酶，其功能是清除细胞中的氢过氧化物酶。本文综述了光合作用生物体中这些酶的功能和相互作用的分子基础。(C)2002 Elsevier Science Inc.保留所有权利。
Thioredoxins are small molecular weight disulfide oxidoreductases specialized in the reduction of disulfide bonds on other proteins. Generally, the enzymes which are selectively and reversibly reduced by these proteins oscillate between an oxidized and inactive conformation and a reduced and active conformation. Thioredoxin constitutes the archetype of a family of protein disulfide oxidoreductases which comprises glutaredoxin and protein disulfide isomerase. Thioredoxin and glutaredoxin serve many roles in the cell, including the redox regulation of target enzymes and transcription factors. They can also serve as hydrogen donors to peroxiredoxins, recently discovered heme free peroxidases, the function of which is to get rid of hydroperoxides in the cell. This review describes the molecular basis for the functioning and interaction between these enzymes in photosynthetic organisms. (C) 2002 Elsevier Science Inc. All rights reserved.