ESTIMATION OF THE NUMBER OF NUCLEOTIDE SUBSTITUTIONS IN THE CONTROL REGION OF MITOCHONDRIAL-DNA IN HUMANS AND CHIMPANZEES
ESTIMATION OF THE NUMBER OF NUCLEOTIDE SUBSTITUTIONS IN THE CONTROL REGION OF MITOCHONDRIAL-DNA IN HUMANS AND CHIMPANZEES
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DOI：
10.1093/oxfordjournals.molbev.a040023
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发表时间：
1993-05-01
影响因子：
10.7
通讯作者：
NEI, M
中科院分区：
文献类型：
--
作者：
TAMURA, K;NEI, M
通过研究人类和黑猩猩线粒体DNA(MtDNA)控制区的核苷酸替换模式，我们发展了一种新的数学方法来估计每个位置的过渡性和横向替换的数量，以及核苷酸替换的总数。在该方法中，考虑了过度的跃迁、不等的核苷酸频率以及不同位点之间的替换率差异。将这种方法应用于人类和黑猩猩的数据表明，整个控制区的转换/颠换比率约为15，这两个物种的转换/颠换比率几乎相同。人类共同祖先线粒体DNA年龄的95%可信区间估计为8万-48万年，普通黑猩猩为0.57-2.72Myr。
Examining the pattern of nucleotide substitution for the control region of mitochondrial DNA (mtDNA) in humans and chimpanzees, we developed a new mathematical method for estimating the number of transitional and transversional substitutions per site, as well as the total number of nucleotide substitutions. In this method, excess transitions, unequal nucleotide frequencies, and variation of substitution rate among different sites are all taken into account. Application of this method to human and chimpanzee data suggested that the transition/transversion ratio for the entire control region was approximately 15 and nearly the same for the two species. The 95% confidence interval of the age of the common ancestral mtDNA was estimated to be 80,000-480,000 years in humans and 0.57-2.72 Myr in common chimpanzees.