Nicotinic acetylcholine receptor alpha7 subunit: a novel therapeutic target for cardiovascular diseases.
Nicotinic acetylcholine receptor alpha7 subunit: a novel therapeutic target for cardiovascular diseases.
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DOI：
10.1007/s11684-012-0171-0
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发表时间：
2012-03-01
影响因子：
8.1
通讯作者：
Su, Dingfeng
中科院分区：
文献类型：
--
作者：
Liu, Chong;Su, Dingfeng
炎症反应在心血管疾病的发生、发展过程中起着重要作用。最近的研究表明，迷走神经刺激通过“胆碱能抗炎途径”，更具体地通过α 7烟碱乙酰胆碱受体（α 7 nAChR）抑制促炎细胞因子的产生。本文综述了胆碱能抗炎通路在感染性休克、高血压和心肌梗死中的作用，并讨论了其在心血管疾病中可能的临床意义。
Inflammation is important in the pathogenesis and development of cardiovascular diseases. Recent studies show that vagus nerve stimulation inhibits pro-inflammatory cytokine production through "the cholinergic anti-inflammatory pathway," more specifically via the alpha7 nicotinic acetylcholine receptor (alpha7nAChR). In the current study, the role of the cholinergic anti-inflammatory pathway during septic shock, hypertension, and myocardial infarction is reviewed, and its possible clinical implications in cardiovascular diseases are discussed.