POLY-UNSATURATED FATTY-ACIDS IN TREATMENT OF ACUTE REMITTING MULTIPLE-SCLEROSIS
POLY-UNSATURATED FATTY-ACIDS IN TREATMENT OF ACUTE REMITTING MULTIPLE-SCLEROSIS
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DOI：
10.1136/bmj.2.6149.1390
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发表时间：
1978-01-01
影响因子：
105.7
通讯作者：
WEIGHTMAN, D
中科院分区：
文献类型：
--
作者：
BATES, D;FAWCETT, PRW;WEIGHTMAN, D
116名急性缓解型多发性硬化症（MS）患者参加了一项多不饱和脂肪酸治疗的双盲对照试验，并被随机分为四组。两组分别服用亚油酸，一组单独涂抹，另一组在胶囊中添加-亚麻酸（Naudicelle）；两组对照组服用油酸，一组是涂抹油酸，另一组是胶囊。治疗组和对照组的临床恶化率和发作频率无显著差异。与对照组相比，接受高剂量亚油酸治疗的患者病情恶化时间较短，严重程度较轻，但接受低剂量亚油酸治疗的患者（即Naudicelle）则没有这种差异。因此，在饮食中添加20 g亚油酸对MS复发的持续时间和严重程度有轻微影响，但对总体残疾没有影响。使用的Naudicelle剂量不能提供足够的补充。
One hundred and sixteen patients with acute remitting multiple sclerosis (MS) took part in a double-blind controlled trial of treatment with polyunsaturated fatty acids and were randomly allocated to one of four groups. Two groups received linoleic acid, one alone as a spread and one with gamma-linolenic acid in capsules (Naudicelle); and two control groups received oleic acid, one as a spread and one in capsules. Rates of clinical deterioration and frequencies of attacks were not significantly different between treated and control groups. Exacerbations were shorter and less severe in patients receiving a high dose of linoleic acid than in controls, but those receiving a lower dose--that is, Naudicelle--showed no such difference. Thus supplementing the diet with 20 g linoleic acid marginally affected the duration and severity of relapses of MS but had no effect on overall disability. The dose of Naudicelle used provided insufficient supplementation.