Role of eIF3a in regulating cell cycle progression
Role of eIF3a in regulating cell cycle progression
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DOI：
10.1016/j.yexcr.2009.03.009
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发表时间：
2009-07-01
影响因子：
3.7
通讯作者：
Zhang, Jian-Ting
中科院分区：
文献类型：
--
作者：
Dong, Zizheng;Liu, Zhaoqian;Zhang, Jian-Ting
翻译调控是基因表达调控中的一个重要过程，它发生在由许多翻译起始因子复合物执行的起始步骤。eIF3a（eIF3 p170）是eIF3复合物的最大亚基。研究表明eIF3a在调节一部分mRNA的翻译以及调节细胞周期进程和细胞增殖方面发挥作用。在这项研究中，我们研究了eIF3a在细胞周期中的表达谱及其在细胞周期进程中的作用。我们发现eIF3a的表达随细胞周期的变化而振荡，在S期达到高峰。降低eIF3a表达也通过延长细胞周期而降低细胞增殖速率，但不改变细胞周期分布。然而，eIF3a似乎在细胞对外部细胞周期调节剂的反应中起重要作用，可能通过影响这些调节剂的靶蛋白的合成。(C)2009 Elsevier Inc. All rights reserved.
Translational control is an essential process in regulation of gene expression, which occurs at the initiation step performed by a number of translation initiation factor complexes. eIF3a (eIF3 p170) is the largest subunit of the eIF3 complex. eIF3a has been suggested to play roles in regulating translation of a subset of mRNAs and in regulating cell cycle progression and cell proliferation. In this study, we examined the expression profile of eIF3a in cell cycle and its role in cell cycle progression. We found that eIF3a expression oscillated with cell cycle and peaked in S phase. Reducing eIF3a expression also reduced cell proliferation rate by elongating cell cycle but did not change the cell cycle distribution. However, eIF3a appears to play an important role in cellular responses to external cell cycle modulators likely by affecting synthesis of target proteins of these modulators. (C) 2009 Elsevier Inc. All rights reserved.