Soda consumption and the risk of stroke in men and women
Soda consumption and the risk of stroke in men and women
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DOI：
10.3945/ajcn.111.030205
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发表时间：
2012-05-01
影响因子：
7.1
通讯作者：
Willett, Walter C.
中科院分区：
文献类型：
--
作者：
Bernstein, Adam M.;de Koning, Lawrence;Willett, Walter C.
背景：食用含糖苏打水会增加心脏代谢性疾病的风险。与脑血管疾病的关系尚未被仔细研究。目的：我们的目标是检验汽水消费和替代饮料的模式与中风风险的关系。设计：护士健康研究，一项对84,085名女性进行的前瞻性队列研究，对84,085名女性进行了长达28年(1980-2008)的跟踪调查；以及卫生专业人员跟踪研究，对43,371名男性进行了22年(1986-2008年)的前瞻性队列研究，提供了有关汽水消费和中风事件的数据。结果：我们记录了在841,770人年的随访中，男性中有1416人中风，在2,188,230人年的随访中，女性中有2938人中风。每天摄入1份含糖苏打水与不摄入相比，总中风的合并RR为1.16(95%CI：1.00，1.34)。每天喝1份低卡路里碳酸饮料与不喝相比，总中风的合并RR为1.16(95%CI：1.05，1.28)，与每天1份含糖苏打水相比，每天1份无咖啡因咖啡与中风风险降低10%(95%CI：1%，19%)，每天1份含咖啡因咖啡的风险降低9%(95%CI：0%，17%)。用含咖啡因或无咖啡因的咖啡替代低卡路里碳酸饮料的风险也有类似的估计降低。结论：摄入更多的含糖和低卡路里碳酸饮料与中风的风险显著增加相关。这种风险可以通过用替代饮料代替苏打水来降低。AM J Clin Nutr 2012；95：1190-9。
Background: Consumption of sugar-sweetened soda has been associated with an increased risk of cardiometabolic disease. The relation with cerebrovascular disease has not yet been closely examined.Objective: Our objective was to examine patterns of soda consumption and substitution of alternative beverages for soda in relation to stroke risk.Design: The Nurses' Health Study, a prospective cohort study of 84,085 women followed for 28 y (1980-2008), and the Health Professionals Follow-Up Study, a prospective cohort study of 43,371 men followed for 22 y (1986-2008), provided data on soda consumption and incident stroke.Results: We documented 1416 strokes in men during 841,770 person-years of follow-up and 2938 strokes in women during 2,188,230 person-years of follow-up. The pooled RR of total stroke for >= 1 serving of sugar-sweetened soda/d, compared with none, was 1.16 (95% Cl: 1.00, 1.34). The pooled RR of total stroke for >= 1 serving of low-calorie soda/d, compared with none, was 1.16(95% CI: 1.05, 1.28), Compared with 1 serving of sugar-sweetened soda/d, 1 serving of decaffeinated coffee/d was associated with a 10% (95% Cl: 1%, 19%) lower risk of stroke and 1 serving of caffeinated coffee/d with a 9% (95% Cl: 0%, 17%) lower risk. Similar estimated reductions in risk were seen for substitution of caffeinated or decaffeinated coffee for low-calorie soda.Conclusions: Greater consumption of sugar-sweetened and low-calorie sodas was associated with a significantly higher risk of stroke. This risk may be reduced by substituting alternative beverages for soda. Am J Clin Nutr 2012;95:1190-9.