DNA methylation and memory formation.
DNA methylation and memory formation.
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DOI：
10.1038/nn.2666
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发表时间：
2010-11
影响因子：
25
通讯作者：
Sweatt, J. David
中科院分区：
文献类型：
--
作者：
Day, Jeremy J.;Sweatt, J. David
Memory formation and storage require long-lasting changes in memory-related neuronal circuits. Recent evidence indicates that DNA methylation may serve as a contributing mechanism in memory formation and storage. These emerging findings suggest a role for an epigenetic mechanism in learning and long-term memory maintenance and raise apparent conundrums and questions. For example, it is unclear how DNA methylation might be reversed during the formation of a memory, how changes in DNA methylation alter neuronal function to promote memory formation, and how DNA methylation patterns differ between neuronal structures to enable both consolidation and storage of memories. Here we evaluate the existing evidence supporting a role for DNA methylation in memory, discuss how DNA methylation may affect genetic and neuronal function to contribute to behavior, propose several future directions for the emerging subfield of neuroepigenetics, and begin to address some of the broader implications of this work.
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影响因子：
4.5
作者：
Jin SG;Guo C;Pfeifer GP
通讯作者：
Pfeifer GP
皮质DNA甲基化保持遥远的记忆。
影响因子：
25
作者：
Miller, Courtney A.;Gavin, Cristin F.;White, Jason A.;Parrish, R. Ryley;Honasoge, Avinash;Yancey, Christopher R.;Rivera, Ivonne M.;Rubio, Maria D.;Rumbaugh, Gavin;Sweatt, J. David
通讯作者：
Sweatt, J. David
Dnmt1 和 Dnmt3a 维持 DNA 甲基化并调节成人前脑神经元的突触功能
影响因子：
25
作者：
Feng, Jian;Zhou, Yu;Campbell, Susan L.;Le, Thuc;Li, En;Sweatt, J. David;Silva, Alcino J.;Fan, Guoping
通讯作者：
Fan, Guoping
影响因子：
2.7
作者：
Miller, Courtney A.;Campbell, Susan L.;Sweatt, J. David
通讯作者：
Sweatt, J. David
DOI：
10.1523/jneurosci.1786-08.2008
发表时间：
2008-10-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lubin FD;Roth TL;Sweatt JD
通讯作者：
Sweatt JD