Antiviral lectins: Selective inhibitors of viral entry.
Antiviral lectins: Selective inhibitors of viral entry.
复制标题
DOI：
10.1016/j.antiviral.2017.03.007
复制
发表时间：
2017-06
影响因子：
7.6
通讯作者：
O'Keefe BR
中科院分区：
文献类型：
--
作者：
Mitchell CA;Ramessar K;O'Keefe BR
据报道，许多天然凝集素具有抗病毒活性。由于其中一些已被提出作为预防或治疗病毒感染的潜在开发候选物，我们在本文中对有关抗病毒凝集素的文献进行了综述。综述了凝集素的结构类别和来源生物类别，并详细介绍了它们的碳水化合物特异性和已报道的抗病毒活性。本综述最后简要讨论了异源蛋白要成为有用的临床候选物必须清除的几个相关障碍，并引用了已报道的用于抗病毒凝集素的此类研究的例子。虽然目前最明确的途径是通过局部粘膜给药使用抗病毒凝集素作为抗hiv杀菌剂，但一些研究人员也发现皮下给药对急性感染有全身疗效。据报道，许多天然凝集素具有抗病毒活性。本文综述了抗病毒凝集素的来源生物。我们讨论了各种抗病毒凝集素的结构类别和碳水化合物特异性。我们详细报道了各种天然凝集素的抗病毒活性。我们讨论了异源蛋白临床应用面临的挑战。
Many natural lectins have been reported to have antiviral activity. As some of these have been put forward as potential development candidates for preventing or treating viral infections, we have set out in this review to survey the literature on antiviral lectins. The review groups lectins by structural class and class of source organism we also detail their carbohydrate specificity and their reported antiviral activities. The review concludes with a brief discussion of several of the pertinent hurdles that heterologous proteins must clear to be useful clinical candidates and cites examples where such studies have been reported for antiviral lectins. Though the clearest path currently being followed is the use of antiviral lectins as anti-HIV microbicides via topical mucosal administration, some investigators have also found systemic efficacy against acute infections following subcutaneous administration. Many natural lectins have been reported to have antiviral activity. This article reviews source organisms for antiviral lectins. We discuss structural classes and carbohydrate specificity for various antiviral lectins. We detail the antiviral activity reported for various natural lectins. We discuss challenges to clinical utility for heterologous proteins.