The Numerous Postulated Biological Manifestations of Interleukin‐1
The Numerous Postulated Biological Manifestations of Interleukin‐1
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Interleukin-1 的众多假设的生物学表现
DOI：
10.1002/jlb.36.3.341
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发表时间：
1984
影响因子：
5.5
通讯作者：
R. Kampschmidt
中科院分区：
文献类型：
--
作者：
R. Kampschmidt
在过去的25年里，人们对控制免疫反应的介质的兴趣不断扩大[98，133]，其中一种由巨噬细胞产生，最初称为“淋巴细胞活化因子”[49-51]，但现在被命名为“白细胞介素-1”（IL-1）[118]。随着IL-1的物理特性开始被描述，人们注意到它们与内源性热原（EP）[128] [151]和白细胞内源性介质（LEM）[85]相似。从那时起，在感染、炎症或肿瘤形成期间宿主中发生的许多生化变化都归因于这个独特的单核因子家族。在本综述中，具有相似物理和生物学特性的单核因子家族将被称为EP/LEM/IL-1。如果仅测量一种生物活性，则指定该活性。本综述的目的是检查表明EP/ LEM/IL-1具有多种生物活性的证据，并描述其化学和生物学特性、种属特异性和可能的作用位点。最后，我将试图解决的问题，为什么可能有一个密切相关的调解人群体的生物活动范围如此之广。
Over the past 25 years there has been an ever‐expanding interest in the mediators that control the immune response [98,133], One of these is produced by macrophages and was first called “lymphocyte activating factor” [49–51] but is now designated “interleukin‐1” (IL‐1) [118]. As the physical characteristics of IL‐1 began to be described, it was noted that they were similar to those of endogenous pyrogen (EP) [128] [151] and leukocytic endogenous mediator (LEM) [85]. Since then, many of the biochemical changes that occur in the host during infection, inflammation, or neoplasia have been attributed to this unique family of monokines. In this review, the family of monokines that has similar physical and biological properties will be referred to as EP/LEM/IL‐1. When only one biological activity was measured, the designation will be for that activity. It will be the purpose of this review to examine the evidence that suggests that EP/ LEM/IL‐1 has numerous biological activites and to describe its chemical and biological properties, species specificity, and possible sites of action. Finally, I will attempt to address the issue of why there might be a closely related group of mediators with such a broad range of biological activities.
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花生四烯酸代谢在人白细胞热原/淋巴细胞激活因子/白细胞介素1免疫调节功能中的作用。
DOI：
--
发表时间：
1983
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Dinarello,CA;Marnoy,SO;Rosenwasser,LJ
通讯作者：
Rosenwasser,LJ
通过佐剂激活的辅助细胞的无细胞因子预防糖皮质激素的免疫抑制作用。
DOI：
10.1016/0162-3109(80)90052-1
发表时间：
1980
期刊：
Immunopharmacology
影响因子：
--
作者：
Mishell,RI;Shiigi,JM;Mishell,BB;Grabstein,KH;Shiigi,SM
通讯作者：
Shiigi,SM
温度对白细胞介素 I 和 II 激活胸腺细胞的影响。
DOI：
--
发表时间：
1983
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hanson,DF;Murphy,PA;Silicano,R;Shin,HS
通讯作者：
Shin,HS
DOI：
--
发表时间：
1982
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Le,PT;Muller,MT;Mortensen,RF
通讯作者：
Mortensen,RF