Antipsychotic-induced tardive dyskinesia and the Ser9Gly polymorphism in the DRD3 gene: A meta analysis
Antipsychotic-induced tardive dyskinesia and the Ser9Gly polymorphism in the DRD3 gene: A meta analysis
复制标题
DOI：
10.1016/j.schres.2006.01.010
复制
发表时间：
2006-04-01
影响因子：
4.5
通讯作者：
van Os, J
中科院分区：
文献类型：
--
作者：
Bakker, PR;van Harten, PN;van Os, J
背景资料：编码多巴胺3受体（DRD 3）的基因中的多态性位点导致丝氨酸（Set）被甘氨酸（Gly）取代，已被证明影响多巴胺结合亲和力，并且可能有助于对抗精神病药诱导的迟发性运动障碍（TD）易感性的个体差异。对1976年至2005年3月间发表的文献进行Medline、EMBASE和PsychINFO检索，获得11项研究，从中提取数据，使用荟萃分析技术计算汇总估计值。Gly等位基因相对于Ser等位基因增加了风险（OR = 1.17; 95%CI：1.01-1.37），并有发表偏倚的证据。没有明显的基因型影响。结论：TD可能与DRD 3等位基因的功能变异有关。然而，在解释这一发现时需要谨慎，因为有证据表明存在出版偏倚，遗传学方法存在缺陷，并且抗精神病药物、精神分裂症和TD之间的关系复杂。(c)2006 Elsevier B. V.保留所有权利。
Background: A polymorphic site in the gene encoding the dopamine 3 receptor (DRD3) resulting in a serine (Set) into glycine (Gly) substitution has been shown to affect dopamine binding affinity, and may contribute to individual differences in susceptibility to antipsychotic-induced tardive dyskinesia (TD).Methods: A Medline, EMBASE and PsychINFO search of literature published between 1976 and March 2005 yielded 11 studies from which data were extracted for calculation of pooled estimates using meta-analytic techniques.Results: The Gly allele increased the risk relative to the Ser allele (OR = 1.17; 95% CI: 1.01-1.37) with evidence of publication bias. No significant genotype effects were apparent.Conclusions: TD may be associated with functional variation in the DRD3 allele. However, caution is required in interpreting this finding, as there is evidence of publication bias, genetic methodology has shortcomings, and the relation between antipsychotics, schizophrenia and TD is complex. (c) 2006 Elsevier B.V. All rights reserved.