Microwave-assisted C-H bond activation: A rapid entry into functionalized heterocycles
Microwave-assisted C-H bond activation: A rapid entry into functionalized heterocycles
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DOI：
10.1021/ol030050j
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发表时间：
2003-06-12
期刊：
影响因子：
5.2
通讯作者：
Souers, AJ
中科院分区：
文献类型：
--
作者：
Tan, KL;Vasudevan, A;Souers, AJ
微波辐射强烈加速了铑催化的苯并咪唑C-H键与侧链烯烃的分子内偶联。环状产物以中等至优异的产率形成，反应时间小于20 min。此外，微波辐射的使用允许反应在没有任何溶剂纯化的情况下进行，并且以最小的预防措施排除空气。
[GRAPHICS]Microwave irradiation strongly accelerates the rhodium-catalyzed intramolecular coupling of a benzimidazole C-H bond to pendant alkenes. The cyclic products were formed in moderate to excellent yields with reaction times less than 20 min. Additionally, the use of microwave irradiation allowed the reactions to be performed without any solvent purification and with minimal precautions to exclude air.