Radiation carcinogenesis: the sequence of events.
Radiation carcinogenesis: the sequence of events.
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辐射致癌：事件的顺序。
DOI：
10.1126/science.150.3705.1782
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发表时间：
1965
期刊：
影响因子：
56.9
通讯作者：
P. Nowell
中科院分区：
文献类型：
--
作者：
L. J. Cole;P. Nowell
在尝试扩展Furth（1）和其他人关于小鼠辐射致癌作用的先驱研究时，我们使用了许多实验方法。对总辐射剂量、剂量率、剂量分数和辐射质量（例如中子与X射线的比较）的变化以及在照射前后对某些靶器官施加增殖刺激的影响都进行了研究。越来越明显的是，诸如剂量-反应曲线（2）或致癌物质的”引发”和非致癌刺激的”促进”（3）等相对简单的概念虽然有用，但不足以解释某些观察到的结果。因此，我们提出了一个概念序列的事件在辐射致癌，试图纳入许多复杂的相互作用，似乎在亚细胞，细胞，和整个动物水平。本文提出了这一观点，并通过我们最近的实验研究结果说明了某些观点。我们认识到，所提供的许多概念不是原创的，许多解释也不是普遍接受的（见4）。提出这一方案的主要目的是将辐射致癌问题中似乎尚未得到普遍承认的某些方面结合在一个统一的理论框架中，并指出值得进一步探讨的领域。
In attempting to extend the pioneer studies of Furth (1) and others on radiation carcinogenesis in mice, we have used a number of experimental approaches. Variationin total radiation dose, dose rate, dose fractiona-tion, and quality of radiation (for ex-ample, neutronsas compared with xrays) have all been investigated as well as the effect of proliferative stimuli applied to certain target organs before and after irradiation. It has be-come increasingly apparent that such relatively simple concepts as dose-re-sponse curves (2) or" initiation" by a carcinogenic agent and" promotion" by a noncarcinogenic stimulus (3), while useful, are not adequate to ex-plain some of the observed results. We have therefore proposeda conceptual sequence of events in radiation carci-nogenesis, attempting to incorporate many of the complex interactions which appear to operate at the subcellular, cellular, and whole-animal levels. In the present article, this out-line is presented, and certain points are illustrated byresults of our recent experimental studies. We recognize that many of the concepts offered are not original and that manyof the assump-tions are not universally accepted (see 4). The chief purpose in present-ing this scheme is to combine in a unified theoretical framework certain aspects of the problem of radiation carcinogenesis which appear not to have been generally recognized and to indicate areas which warrant further exploration.