IL-21 enhances mast cell accumulation in the intestine and exacerbates the development of experimental food allergy.
IL-21 enhances mast cell accumulation in the intestine and exacerbates the development of experimental food allergy.
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IL-21 会增强肠道内肥大细胞的积累，并加剧实验性食物过敏的发生。
DOI：
10.1111/cea.13473
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Nakajima H.
中科院分区：
文献类型：
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作者：
Kono K;Hirose K;Makita S;Kageyama T;Tamachi T;Saku A;Suto A;Suzuki K;Nakajima H.
IL-21增强肥大细胞在肠中的积聚并加剧实验性食物过敏的发展IgE介导的食物过敏，其中症状从轻度皮肤反应到过敏性休克变化，是由IgE介导的肥大细胞活化对抗摄入的食物抗原引起的病理状况。因为据报道肥大细胞活化在该模型中是至关重要的，[5]肠中肥大细胞积累减少似乎是IL-21 R i SP-/-sp小鼠中针对食物过敏症状的保护的部分原因。鉴于Th 2细胞与ILC 2s合作发展IgE介导的肥大细胞依赖性食物过敏，[6]我们的结果表明IL-21可以通过增强Th 2细胞和ILC 2s在肠道中的积累来放大肠道肥大细胞增多症。本网站的版权属于Wiley-Blackwell所有，未经版权保持器的明确书面许可，不得将其内容复制或通过电子邮件发送到多个网站或发布到列表服务器。但是，用户可以打印，下载或电子邮件的文章供个人使用。这篇摘要可以删节。对副本的准确性不作任何保证。用户应参考材料的原始出版版本以获取完整摘要。版权适用于所有摘要。
IL-21 enhances mast cell accumulation in the intestine and exacerbates the development of experimental food allergy IgE-mediated food allergy in which symptoms vary from mild skin reaction to anaphylactic shock is a pathological condition caused by IgE-mediated mast cell activation against ingested food antigens. Because mast cell activation is reported to be crucial in this model,[5] the reduced mast cell accumulation in the intestines seems to be responsible in part for the protection against food allergy symptoms in I IL-21R i SP-/-sp mice. Given that Th2 cells collaborate with ILC2s to develop IgE-mediated mast cell-dependent food allergy,[6] our results suggest that IL-21 could amplify intestinal mastocytosis by enhancing the accumulation of Th2 cells and ILC2s in the intestine.[Extracted from the article]Copyright of Clinical & Experimental Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.