Effects of acute and long-term treatment with methamphetamine on substance P concentration and receptor numbers in the rat brain
Effects of acute and long-term treatment with methamphetamine on substance P concentration and receptor numbers in the rat brain
复制标题
甲基苯丙胺急性和长期治疗对大鼠脑内P物质浓度和受体数量的影响
DOI：
10.1016/0006-8993(88)90151-5
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发表时间：
1988
期刊：
影响因子：
2.9
通讯作者：
S. Otsuki
中科院分区：
文献类型：
--
作者：
H. Ujike;N. Ogawa;S. Otsuki
To examine biochemical changes in brain substance P (SP) systems associated with development of behavioral sensitization induced by methamphetamine (MAP), regional substance P-like immunoreactivity (SP-LI) and SP receptor binding in the rat brain were measured after acute and long-term MAP administration. Single administration of 8 mg/kg MAP significantly reduced the striatal SP-LI concentration 1 h after the injection. This reduction was blocked by pretreatment with haloperidol. Although repeated administration of 4 mg/kg MAP for 14 consecutive days did not affect the SP-LI concentration in any brain regions including the striatum, it decreased specific SP receptor binding in the striatum and increased those in the frontal cortex. Scatchard analysis of saturation isotherm of specific SP binding revealed that the decreased specific SP binding in the striatum resulted from a decrease in the maximal number (Bmax) of SP receptors and that increased binding in the frontal cortex resulted from an increase inBmax. These changes in SP receptor binding lasted for at least 7 days. It is emphasized that the persisting changes induced by long-term MAP administration in the SP receptor may contribute to behavioral sensitization to MAP in rats and may be associated with neuronal mechanisms in MAP psychosis.
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影响因子：
21.1
作者：
M. Bannon;R. Roth
通讯作者：
M. Bannon;R. Roth
亚急性甲基苯丙胺治疗后纹状体黑质结构内 P 物质样免疫反应性增加。
DOI：
--
发表时间：
1984
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Ritter,JK;Schmidt,CJ;Gibb,JW;Hanson,GR
通讯作者：
Hanson,GR
中脑边缘 P 物质系统对甲基苯丙胺治疗的反应。
影响因子：
5
作者：
Hanson,GR;Ritter,JK;Schmidt,CJ;Gibb,JW
通讯作者：
Gibb,JW
纹状体黑质 P 系统对 D1 和 D2 受体激活的相反反应。
影响因子：
5
作者：
Sonsalla,PK;Gibb,JW;Hanson,GR
通讯作者：
Hanson,GR