PLASMA-LIPIDS AND DIABETES-MELLITUS IN AN ADULT COMMUNITY
PLASMA-LIPIDS AND DIABETES-MELLITUS IN AN ADULT COMMUNITY
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DOI：
10.1093/oxfordjournals.aje.a113348
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发表时间：
1982-01-01
影响因子：
5
通讯作者：
HOLDBROOK, MJ
中科院分区：
文献类型：
--
作者：
BARRETTCONNOR, E;GRUNDY, SM;HOLDBROOK, MJ
以往大多数关于糖尿病患者高脂血症的研究都是基于专科诊所的患者，或者反映了糖尿病患者食用高脂肪、低碳水化合物饮食的时代。 1972-1974 年美国南加州一个中上阶层社区的 20-79 岁成年人群的数据被用来确定当前社区人群中高脂血症与糖尿病的关系。将所有 (358) 名根据病史和/或空腹高血糖定义的糖尿病患者（空腹血糖，> 140 mg/dl）与所有 (n 4387) 定义为血糖正常（空腹血糖，< 110 mg/dl）且没有个人或家族糖尿病史的非糖尿病患者进行比较。在 50 岁及以上的男性和女性中，糖尿病患者与非糖尿病患者的平均胆固醇水平和分类高胆固醇血症的患病率没有显着差异，而糖尿病患者的平均甘油三酯水平和分类高甘油三酯血症的患病率显着高于非糖尿病患者。对 356 名年龄和肥胖程度相匹配的糖尿病患者与 356 名非糖尿病患者进行病例对照比较，证实了糖尿病患者的甘油三酯水平显着升高。相反，高甘油三酯血症与糖尿病相关的比例在非肥胖男性中为 29%，在肥胖男性中为 25%，在非肥胖女性中为 10%，在肥胖女性中为 21%。讨论了糖尿病患者高甘油三酯血症的生物学机制。
Most previous studies of hyperlipidemia in diabetics are based on patients in specialty clinics or reflect an era when diabetics consumed a high-fat, low-carbohydrate diet. Data from a defined adult population aged 20-79 yr in an upper middle class community in Southern California, USA, 1972-1974, were used to ascertain the relationship of hyperlipidemia to diabetes in a current community-based population. All (358) diabetics as defined by history and/or fasting hyperglycemia (fasting plasma glucose, .gtoreq. 140 mg/dl) were compared with all (n 4387) nondiabetics defined as euglycemic (fasting plasma glucose, < 110 mg/dl) with no personal or family history of diabetes. In both men and women 50 yr of age and older, the mean cholesterol level and the prevalence of categorical hypercholesterolemia were not significantly different in diabetics vs. nondiabetics, whereas the mean triglyceride level and the prevalence of categorical hypertriglyceridemia were significantly higher in diabetics vs. nondiabetics. Case-control comparisons of 356 diabetics matched for age and obesity with 356 nondiabetics confirmed the significantly higher triglyceride levels in diabetes. Conversely, hypertriglyceridemia was associated with diabetes in 29% of nonobese men and 25% of obese men, and in 10% of non-obese women and 21% of obese women. The biologic mechanism of hypertriglyceridemia in diabetics is discussed.