Similarities and differences between the risk factors for gestational hypertension and preeclampsia: A population based cohort study in south China
Similarities and differences between the risk factors for gestational hypertension and preeclampsia: A population based cohort study in south China
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DOI：
10.1016/j.preghy.2015.11.004
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发表时间：
2016-01-01
影响因子：
2.2
通讯作者：
Wen, Shi Wu
中科院分区：
文献类型：
--
作者：
Li, Xun;Tan, Hongzhuan;Wen, Shi Wu
目的：比较同一人群中妊娠期高血压（GH）和先兆子痫（PE）的危险因素，为更好地了解其病因机制提供线索。方法：我们在2010-2011年在中国浏阳进行了一项队列研究。调查了12个潜在危险因素，包括母亲年龄、首次产前检查时的体重指数、新生儿性别、产次、流产史、吸烟史、高血压家族史、妊娠期糖尿病、妊娠合并糖尿病/肾脏疾病/心脏病、生殖道感染、分娩季节和地区人均收入。结果：6223例妊娠合并PE占1.8%，GH占5.4%。母亲年龄大于35岁、体重指数大于24、妊娠合并妊娠期糖尿病均增加PE和GH的发生风险，但效应量不同。初产和冬春产（与夏产相比）是GH的危险因素。妊娠合并糖尿病/肾脏疾病/心脏病仅是PE的危险因素。25岁以下或体重指数较低的女性在孕早期患生长激素的风险显著降低。携带男性胎儿的母亲更容易发展PE。结论：GH和PE的危险因素并不完全相同。这些差异的基础可能是它们不同的病因和机制。为了证实在单个研究中发现的相似性和差异性，在其他人群中进行调查是重要的。(C)2015年国际妊娠高血压研究学会。Elsevier B. V.出版，保留所有权利。
Objectives: To compare the risk factors for gestational hypertension (GH) and preeclampsia (PE) in the same population, which may provide clues to better understanding of their etiologic mechanisms.Methods: We conducted a cohort study in Liuyang, China, during 2010-2011. Twelve potential risk factors were investigated, including maternal age, body mass index at first antenatal visit, gender of newborn, parity, abortion history, smoking history, family history of hypertension, gestational diabetes mellitus, pregnancy complications of diabetes mellitus/renal disease/cardiac disease, reproductive tract infection, season of deliveiy, and district level average per capita income. Logistic regression were used to estimate odds ratios for potential risk factors.Results: Of 6223 pregnancies, 1.8% was complicated by PE, and 5.4% by GH. Maternal age older than 35, body mass index above 24, and pregnancy complicated with gestational diabetes mellitus increased the risk of both PE and GH, while with different effect sizes. Primiparity and deliver in winter and spring (compared with summer delivery) were risk factors for GH only. Pregnancy complicated with diabetes mellitus/renal disease/cardiac disease was risk factor for PE only. Significantly lower risk of GH was observed for women younger than 25 or with low body mass index in the first trimester. Mothers carrying a male fetus were more likely to develop PE.Conclusions: Risk factors for GH and PE were not exactly the same. Underling those differences might be their different etiology and mechanism. To confirm the similarities and differences been found in single study, it is important to conduct investigation in other population. (C) 2015 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.