Preparation of biocompatible nanocapsules with temperature-responsive and bioreducible properties
Preparation of biocompatible nanocapsules with temperature-responsive and bioreducible properties
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DOI：
10.1039/c1jm12570b
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发表时间：
2011-10
影响因子：
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通讯作者：
Zhongkai Wang;Di Wang;Hua Wang;Junjie Yan;Yezi You;Zhi Wang
中科院分区：
文献类型：
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作者：
Zhongkai Wang;Di Wang;Hua Wang;Junjie Yan;Yezi You;Zhi Wang
刺激响应型生物相容性纳米载体对于控制药物释放非常有前景。在这里，我们报告了氧化还原和温度响应型生物相容性纳米胶囊，其制备方法是通过沉淀聚合从甲基丙烯酸3-（三甲氧基硅烷基）丙酯改性二氧化硅纳米颗粒（SiO2-MPS）中生长温度响应型生物相容性壳，用可生物还原的化学键交联壳，然后通过氢氟酸蚀刻去除二氧化硅核。所生产的纳米胶囊具有氧化还原和温度响应性。使用 TEM、FT-IR、TGA 和 XPS 来表征纳米胶囊。进行动态光散射（DLS）以证明纳米胶囊的生物可还原性和温度响应特性。纳米胶囊的下临界溶解温度（LCST）可以精确调节。将异硫氰酸荧光素（FITC）封装在纳米胶囊中，并用作模型药物分子，以证明在外部刺激下的控释行为。
Stimuli-responsive biocompatible nanocarriers are very promising for controlled drug release. Here, we report redox- and temperature-responsive biocompatible nanocapsules prepared by growing a temperature-responsive biocompatible shell from 3-(trimethoxysilyl)propyl methacrylate-modified silica nanoparticles (SiO2-MPS) viaprecipitation polymerization, cross-linking the shell with bioreducible chemical linkages, and subsequently removing the silica core by hydrofluoric acid etching. The produced nanocapsules are redox- and temperature-responsive. TEM, FT-IR, TGA, and XPS were used to characterize the nanocapsules. Dynamic light scattering (DLS) was performed to demonstrate the bioreducible and temperature-responsive properties of the nanocapsules. The lower critical solution temperature (LCST) of the nanocapsules can be tuned precisely. Fluorescein isothiocyanate (FITC) was encapsulated into the nanocapsules and used as a model drug molecule to demonstrate the controlled release behavior under external stimuli.