Misuse of corticosteroid metered-dose inhaler is associated with decreased asthma stability
Misuse of corticosteroid metered-dose inhaler is associated with decreased asthma stability
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DOI：
10.1183/09031936.02.00218402
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发表时间：
2002-02-01
影响因子：
24.3
通讯作者：
Roche, N
中科院分区：
文献类型：
--
作者：
Giraud, V;Roche, N
本研究评估了不正确使用加压计量吸入器（pMDI）是否与吸入性皮质类固醇（ICS）治疗的哮喘患者的哮喘控制下降有关。全科医生（GP）包括连续的哮喘门诊患者，这些患者接受了pMDI给药的ICS和按需短效β 2受体激动剂治疗。他们根据日间和夜间症状、运动引起的呼吸困难、β 2受体激动剂的使用、急诊就诊和前一个月内对哮喘控制的总体感知来测量哮喘不稳定性评分（AIS）;还评估了患者的吸入技术。全科医生（n=915）包括4，078名成人哮喘患者; 3，955份问卷可评估。71%的患者误用pMDI，其中47%是由于协调不良。pMDI滥用者的哮喘稳定性低于良好使用者（AIS：3.93 vs 2.86，p
This study assessed whether the improper use of pressurized metered-dose inhalers (pMDIs) is associated with decreased asthma control in asthmatics treated by inhaled corticosteroids (ICS).General practitioners (GPs) included consecutive asthmatic outpatients treated by pMDI-administered ICS and on-demand, short-acting beta(2)-agonists. They measured an asthma instability score (AIS) based on daytime and nocturnal symptoms, exercise-induced dyspnoea, beta(2)-agonist usage, emergency-care visits and global perception of asthma control within the preceding month; the inhalation technique of the patient also was assessed.GPs (n=915) included 4,078 adult asthmatics; 3,955 questionnaires were evaluable. pMDI was misused by 71% of patients, of which 47%, was due to poor coordination. Asthma was less stable in pMDI misusers than in good users (AIS: 3.93 versus 2.86, p