Multiple evanescent white dot syndrome (MEWDS).
Multiple evanescent white dot syndrome (MEWDS).
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DOI：
10.1097/iio.0b013e31826647ed
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Pavesio, Carlos E
中科院分区：
文献类型：
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作者：
dell'Omo, Roberto;Pavesio, Carlos E
多发性渐逝性白色斑点综合征（MEWDS）是由Jampol等1和Sieving等2于1984年首次报道的一种脉络膜视网膜病变。在大约三分之一的病例中，这种疾病是由病毒样疾病引起的，通常发生在年轻的近视患者中，特别是女性。没有已知的种族或遗传偏好。与HLA-B51相关。3患者主诉突发性视力下降，伴有视野缺损，表现为旁中心暗点或盲点扩大，有时伴有视物模糊和色觉障碍。尽管最初被描述为一种急性、单侧疾病，具有自限性病程和异常快速消退，但MEWDS实际上可能累及双眼、复发，并因脉络膜新生血管和脉络膜视网膜疤痕晚期发展而变得复杂。4-7此外，MEWDS可能与其他炎性疾病相关、在其之前或之后，如急性黄斑神经视网膜病变，8多灶性脉络膜炎和全葡萄膜炎，9，10或急性带状隐匿性外层视网膜病变。11
Multiple evanescent white dot syndrome (MEWDS) is a chorioretinopathy first reported by Jampol et al 1 and Sieving et al 2 in 1984. This disorder is preceded by a viral-like illness in about one third of cases and typically occurs in young myopic individuals, particularly women. There are no known racial or hereditary predilections. An association with HLA-B51 has been reported. 3Affected patients complain of sudden-onset vision loss accompanied by visual field defects in the form of paracentral scotomas or enlargement of the blind spot, sometimes associated with photopsias and dyschromatopsia. Although originally described as an acute, unilateral disorder with a self-limiting course and a rapid resolution of abnormalities, MEWDS can actually involve both eyes, recur, and be complicated by choroidal neovascularization and late development of chorioretinal scars. 4–7 Furthermore, MEWDS can be associated, preceded, or followed by other inflammatory conditions such as acute macular neuroretinopathy, 8 multifocal choroiditis, and panuveitis, 9, 10 or acute zonal occult outer retinopathy. 11