Interfacial Photo-Cross-Linking: Simple but Powerful Approach for Fabricating Capsule Polymer Particles with Tunable pH-Responsive Controlled Release Capability.
Interfacial Photo-Cross-Linking: Simple but Powerful Approach for Fabricating Capsule Polymer Particles with Tunable pH-Responsive Controlled Release Capability.
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界面光交联：简单但强大的方法，用于制造具有可调 pH 响应控制释放能力的胶囊聚合物颗粒。
DOI：
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发表时间：
2021
影响因子：
9.5
通讯作者：
Atsushi Harada
中科院分区：
文献类型：
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作者：
Yukiya Kitayama;Atsushi Harada
本文中，我们描述了通过球形聚（甲基丙烯酸2-二乙基氨基乙酯-共-2-肉桂酰乙基甲基丙烯酸酯）（P（DEAEMA-CEMA））颗粒的界面光交联直接制备的具有精确控制的pH响应释放性质的胶囊聚合物颗粒。在界面光交联中，聚合物粒子中的光反应性肉桂酰基通过[2π + 2π]环加成反应在聚合物/水界面发生交联，表明球形聚合物粒子可以直接制备壳交联中空聚合物粒子。该方法具有令人着迷的优点，如使用最少的组件，简单，不需要牺牲模板颗粒和有毒溶剂。进行了以下重要观察：（I）包封的材料在中性pH条件下稳定地保留在胶囊颗粒中;（II）包封的材料在酸性pH条件下从胶囊颗粒中释放;（III）包封的材料的释放动力学受pH条件控制;即，通过改变水相介质的酸度实现了速释和缓释;（IV）在不同pH条件下，光照射时间对释放动力学没有显著影响;（V）通过改变P（DEAEMA-CEMA）中的聚合物组成来调节pH响应性释放特性。此外，通过利用pH响应性，胶囊颗粒通过全水性方法从球形聚合物颗粒成功地获得。全水包封工艺的优点使得水溶性生物大分子如DNA和β-内酰胺被成功地包封在P（DEAEMA-CEMA）中空粒子中。通过这种简单的界面光交联策略，我们设想了在先进研究领域广泛应用的复杂颗粒材料的现成合成。
Herein, we describe capsule polymer particles with precisely controlled pH-responsive release properties prepared directly via the interfacial photo-cross-linking of spherical poly(2-diethylaminoethyl methacrylate-co-2-cinnamoylethyl methacrylate) (P(DEAEMA-CEMA)) particles. In the interfacial photo-cross-linking, photoreactive cinnamoyl groups in the polymer particles were cross-linked via [2π + 2π] cycloaddition reactions at the polymer/water interface, showing that the shell-cross-linked hollow polymer particles can be directly prepared from spherical polymer particles. The approach has fascinating advantages such as using minimal components, simplicity, and not requiring sacrificial template particles and toxic solvents. The following important observations are made: (I) encapsulated materials were stably retained in the capsule particles under neutral pH conditions; (II) encapsulated materials were released from the capsule particles under acidic pH conditions; (III) the release kinetics of encapsulated materials were controlled by the pH conditions; i.e., immediate and sustained release was achieved by varying the acidity of the aqueous media; (IV) the photoirradiation time did not significantly affect the release kinetics under different pH conditions; and (V) the pH-responsive release properties were regulated by changing the polymer composition in P(DEAEMA-CEMA). Furthermore, by exploiting the pH-responsiveness, capsule particles are successfully obtained via an all-aqueous process from spherical polymer particles. The advantages of the all-aqueous encapsulation process allowed the water-soluble biomacromolecules such as DNA and saccharides to be successfully encapsulated in the P(DEAEMA-CEMA) hollow particles. With this simple interfacial photo-cross-linking strategy, we envision the ready synthesis of sophisticated particulate materials for broad application in advanced research fields.