Multimodal quantitative magnetic resonance imaging of thalamic development and aging across the human lifespan: implications to neurodegeneration in multiple sclerosis.
Multimodal quantitative magnetic resonance imaging of thalamic development and aging across the human lifespan: implications to neurodegeneration in multiple sclerosis.
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DOI：
10.1523/jneurosci.4184-11.2011
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发表时间：
2011-11-16
期刊：
影响因子：
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通讯作者：
Narayana PA
中科院分区：
文献类型：
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作者：
Hasan KM;Walimuni IS;Abid H;Frye RE;Ewing-Cobbs L;Wolinsky JS;Narayana PA
人脑丘脑在整合认知、感觉和运动功能方面发挥着重要作用。在多发性硬化症 (MS) 中，丘脑的定量磁共振成像 (qMRI) 测量提供了疾病进展的重要生物标志物，但晚期发育和衰老混淆了从广泛年龄范围的患者收集的数据的解释。先前尚未研究过自然衰老导致的丘脑组织体积损失及其与病变驱动病理学的相互作用。在这项工作中，我们对大量对照组（N = 255，年龄范围 = 6.2-69.1 岁）和 MS 患者（N = 109，年龄范围 = 20.8-68.5 岁）使用标准化丘脑容量法结合扩散张量成像 (DTI)、T2 松弛测量和病变映射，以证明早期与年龄和病变无关的丘脑神经变性。
The human brain thalami play essential roles in integrating cognitive, sensory and motor functions. In multiple sclerosis (MS), quantitative magnetic resonance imaging (qMRI) measurements of the thalami provide important biomarkers of disease progression, but late development and aging confound the interpretation of data collected from patients over a wide age range. Thalamic tissue volume loss due to natural aging and its interplay with lesion-driven pathology has not been investigated previously. In this work, we used standardized thalamic volumetry combined with diffusion tensor imaging (DTI), T2 relaxometry and lesion mapping on large cohorts of controls (N = 255, age range = 6.2- 69.1 years) and MS patients (N=109, age range = 20.8–68.5 years) to demonstrate early age- and lesion-independent thalamic neurodegeneration.