The cell biology of the innate immune response to Aspergillus fumigatus
The cell biology of the innate immune response to Aspergillus fumigatus
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DOI：
10.1111/j.1749-6632.2012.06837.x
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Vyas, Jatin M.
中科院分区：
文献类型：
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作者：
Mansour, Michael K.;Tam, Jenny M.;Vyas, Jatin M.
侵袭性曲霉菌病的发展是免疫功能低下患者的一个可怕的并发症。尽管使用具有良好生物活性的抗真菌药物，侵袭性曲霉病的发病率和死亡率仍然高得令人无法接受。先天免疫反应中的缺陷预示着患者的最高风险，但缺乏对中性粒细胞和巨噬细胞中响应这种真菌病原体的分子途径的详细了解。真菌孢子的吞噬作用是将病原体置于吞噬体中的关键步骤，吞噬体是经历成熟并最终将抗原物质递送至II类MHC途径的膜界定的隔室。本文综述了Toll样受体9（TLR9）在烟曲霉吞噬体成熟过程中的作用。先进的成像方式和真菌样颗粒的发展是很有前途的工具，将有助于解剖真菌免疫的分子机制。
The development of invasive aspergillosis is a feared complication for immunocompromised patients. Despite the use of antifungal agents with excellent bioactivity, the morbidity and mortality rates for invasive aspergillosis remain unacceptably high. Defects within the innate immune response portend the highest risk for patients, but detailed knowledge of molecular pathways in neutrophils and macrophages in response to this fungal pathogen is lacking. Phagocytosis of fungal spores is a key step that places the pathogen into a phagosome, a membrane-delimited compartment that undergoes maturation and ultimately delivers antigenic material to the class II MHC pathway. We review the role of Toll-like receptor 9 (TLR9) in phagosome maturation of Aspergillus fumigates-containing phagosomes. Advanced imaging modalities and the development of fungal-like particles are promising tools that will aid in the dissection of the molecular mechanism to fungal immunity.