Single-Fraction Carbon-Ion Radiation Therapy for Patients 80 Years of Age and Older With Stage I Non-Small Cell Lung Cancer
Single-Fraction Carbon-Ion Radiation Therapy for Patients 80 Years of Age and Older With Stage I Non-Small Cell Lung Cancer
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DOI：
10.1016/j.ijrobp.2015.11.034
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发表时间：
2016-05-01
影响因子：
7
通讯作者：
Kamada, Tadashi
中科院分区：
文献类型：
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作者：
Karube, Masataka;Yamamoto, Naoyoshi;Kamada, Tadashi
目的：在老龄化社会，许多老年人希望减少侵入性治疗，因为潜在的医疗并发症。国家放射科学研究所已经开始用单次碳离子放射疗法（CIRT）治疗I期肺癌，作为剂量递增前瞻性1/2期试验。我们评估了CIRT的疗效和安全性为80岁及以上的患者，进行单馏分CIRT.Methods和材料：周围非小细胞肺癌患者谁是单馏分CIRT治疗的前瞻性随访。我们分析了80岁及以上患者的数据。中位年龄为83岁（范围：80-89岁），中位随访期为42.7个月（范围：12-128个月）。3年局部控制率、病因特异性生存率和总生存率分别为88.0%、81.6%和72.4%。5年局部控制率、病因特异性生存率和总生存率分别为85.8%、64.9%和39.7%。无论是急性期还是晚期，皮肤和肺部均未出现2级以上的不良反应。镇痛剂是必要的，只有5例（7.1%），以减轻肌肉或肋骨骨折疼痛引起的radiation.Conclusions：单馏分CIRT是低风险和有效的，即使是老年人。(C)2016 Elsevier Inc. All rights reserved.
Purpose: In an aging society, many senior citizens want less invasive treatment because of potential medical complications. The National Institute of Radiological Sciences has started to treat stage I lung cancer with single-fraction carbon-ion radiation therapy (CIRT) as a dose escalation prospective phase 1/2 trial. We evaluated the efficacy and safety of CIRT for patients 80 years of age and older, undergoing single-fraction CIRT.Methods and Materials: Peripheral non-small cell lung cancer patients who were treated with single-fraction CIRT were prospectively followed. We analyzed the data from among these patients 80 years of age and older.Results: There were 70 patients. Median age was 83 years (range: 80-89) and median follow-up period was 42.7 months (range: 12-128 months). Three-year local control, cause-specific survival, and overall survival rates were 88.0%, 81.6%, and 72.4%, respectively. Five-year local control, cause-specific survival, and overall survival rates were 85.8%, 64.9%, and 39.7%, respectively. There were no adverse effects higher than grade 2 either in the acute or late phase in terms of skin and lung. Analgesic agents were necessary for only 5 patients (7.1%), to relieve muscular or rib fracture pain caused by irradiation.Conclusions: Single-fraction CIRT was low-risk and effective, even for the elderly. (C) 2016 Elsevier Inc. All rights reserved.