Neuroscience. A CRY to rise.
Neuroscience. A CRY to rise.
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神经科学。
DOI：
10.1126/science.1204293
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Taghert,PaulH
中科院分区：
文献类型：
--
作者：
Im,SeolHee;Taghert,PaulH
当我们需要在特定的时间醒来时，我们中的一些人会在不同的时间或不同的地点设置几个闹钟，以确保我们不会睡过头。生物计时系统似乎使用了类似的策略：它依赖于多层方法来检测环境信号，并提供有关环境光线条件的多方面信息。在果蝇体内，一种名为CRYPTOCHROME （CRY）的光敏蛋白就像一种光传感器，每天帮助果蝇重置生物钟。在本期的第1409页，Fogleet等人表明，CRY还通过感知蓝色波长的光，直接增加了关键的昼夜节律“起搏器”神经元的放电率。这代表了一种不基于视蛋白的神经元光激活机制，视蛋白通常参与大脑的光反应活动。
When we need to wake at a certain time, some of us resort to setting several alarm clocks to ring at different times, or in different locations, to ensure that we don't oversleep. The biological timing system appears to use a similar strategy: It relies on a multi-tiered approach to detect environmental signals and deliver multifaceted information regarding ambient light conditions. InDrosophila, a light-sensitive protein called CRYPTOCHROME (CRY) serves as a light sensor that each day helps to reset the fly's circadian clock. On page 1409 of this issue, Fogleet al.show that CRY also directly increases the firing rate of critical circadian “pacemaker” neurons by sensing blue wavelengths of light. This represents a mechanism for photo-activation of neurons that is not based on opsin, the protein typically involved in light-responsive brain activity.