Randomized, Controlled Trial of Yoga in Women With Breast Cancer Undergoing Radiotherapy
Randomized, Controlled Trial of Yoga in Women With Breast Cancer Undergoing Radiotherapy
复制标题
DOI：
10.1200/jco.2012.48.2752
复制
发表时间：
2014-04-01
影响因子：
45.3
通讯作者：
Cohen, Lorenzo
中科院分区：
文献类型：
--
作者：
Chandwani, Kavita D.;Perkins, George;Cohen, Lorenzo
目的先前将瑜伽(YG)与放射治疗(XRT)相结合的研究发现，女性乳腺癌患者的生活质量(QOL)得到改善。然而，这项研究的不足限制了研究结果的获得。患者和方法乳腺癌患者在开始XRT前被随机分配到YG组(n=53)或伸展运动(ST；n=56)，在XRT或等待名单(WL；n=54)对照组中，每周3次，共6周。分别于治疗前、治疗结束、治疗后1、3、6个月收集生活质量、疲劳感、抑郁、睡眠质量和连续3天的生活质量自评量表。结果治疗后1个月和3个月，YG组的身体成分量表得分均显著高于WL组(P=.01和P=.01)。在1、3和6个月时，YG组的身体功能较ST组和WL组有更大的提高(P<；0.05)，ST组和WL组仅在3个月时有差异(P<；0.02)。在一般健康报告中，组内差异相似。在XRT结束时，YG组和ST组的疲劳程度也有所减少(P<；0.05)。在心理健康和睡眠质量方面没有组间差异。YG组的皮质醇斜率在XRT结束时(P=0.023和P=0.008)和XRT后1个月(P=0.05和P=0.04)明显高于ST组和WL组(P=0.05和P=0.04)。结论YG组改善生活质量和XRT相关的生理改变优于单纯ST运动，这些益处似乎具有长期的持久性。
Purpose Previous research incorporating yoga (YG) into radiotherapy (XRT) for women with breast cancer finds improved quality of life (QOL). However, shortcomings in this research limit the findings.Patients and Methods Patients with stages 0 to III breast cancer were recruited before starting XRT and were randomly assigned to YG (n = 53) or stretching (ST; n = 56) three times a week for 6 weeks during XRT or waitlist (WL; n = 54) control. Self-report measures of QOL (Medical Outcomes Study 36-item short-form survey; primary outcomes), fatigue, depression, and sleep quality, and five saliva samples per day for 3 consecutive days were collected at baseline, end of treatment, and 1, 3, and 6 months later.Results The YG group had significantly greater increases in physical component scale scores compared with the WL group at 1 and 3 months after XRT (P = .01 and P = .01). At 1, 3, and 6 months, the YG group had greater increases in physical functioning compared with both ST and WL groups (P < .05), with ST and WL differences at only 3 months (P < .02). The group differences were similar for general health reports. By the end of XRT, the YG and ST groups also had a reduction in fatigue (P < .05). There were no group differences for mental health and sleep quality. Cortisol slope was steepest for the YG group compared with the ST and WL groups at the end (P = .023 and P = .008) and 1 month after XRT (P = .05 and P = .04).Conclusion YG improved QOL and physiological changes associated with XRT beyond the benefits of simple ST exercises, and these benefits appear to have long-term durability.