N,N′-Dioxide-Cu(OTf)2 Complex Catalyzed Highly Enantioselective Amination Reaction of N-Acetyl Enamide
N,N′-Dioxide-Cu(OTf)2 Complex Catalyzed Highly Enantioselective Amination Reaction of N-Acetyl Enamide
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DOI：
10.1021/ol100540p
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发表时间：
2010-05-21
期刊：
影响因子：
5.2
通讯作者：
Feng, Xiaoming
中科院分区：
文献类型：
--
作者：
Chang, Lu;Kuang, Yulong;Feng, Xiaoming
The N,N'-dioxide-Cu(OTf)(2) complexes were applied in,the asymmetric amination reaction of N-acetyl enamides with dialkyl azodicarboxylate, giving the corresponding products in good yields with high enantioselectivities (up to 91% ee). Precursors of vicinal diamine were readily obtained with excellent diastereoselectivities (>95:5) by NaBH4 reduction.
