Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline-induced Model of Essential Tremor in Rats.
Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline-induced Model of Essential Tremor in Rats.
复制标题
低剂量普拉克索对骆驼蓬碱诱发的特发性震颤大鼠模型产生有益作用。
DOI：
10.1111/cns.12467
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发表时间：
2016
影响因子：
5.5
通讯作者：
Ossowska,Krystyna
中科院分区：
文献类型：
--
作者：
Kosmowska,Barbara;Wardas,Jadwiga;Głowacka,Urszula;Ananthan,Subramaniam;Ossowska,Krystyna
AimsThe aim of the study was to examine the effects of preferential agonists of dopamine D3 receptors: pramipexole and 7‐OH‐DPAT on the harmaline‐induced tremor in rats (a model of essential tremor, ET). To study receptor mechanisms of these drugs, rats were pretreated with dopamine D3 receptor antagonists—SB‐277011‐A and SR‐21502, an antagonist of presynaptic D2/D3 receptors—amisulpride, or a nonselective antagonist of D2‐like receptors, haloperidol, at a postsynaptic dose.MethodsFor tremor measurement, fully automated force plate actimeters were used and data were analyzed using fast Fourier transform.ResultsHarmaline (15 mg/kgip)‐triggered tremor was manifested by an increase in the power within 9–15 Hz band (AP2). Pramipexole administered at a low (0.1 mg/kgsc), but not higher doses (0.3 and 1 mg/kgsc), and 7‐OH‐DPAT (0.1, 0.3, and 1 mg/kgsc) reversed the harmaline‐increased AP2. None of the examined dopamine antagonists: SB‐277011‐A (10 mg/kgip), SR‐21502 (15 mg/kgip), haloperidol (0.5 mg/kgip), or amisulpride (1 mg/kgip) influenced the above effect of dopamine agonists.ConclusionThe present study indicates that pramipexole reduces the harmaline‐induced tremor, which may suggest its beneficial effects in ET patients. However, mechanisms underlying its action are still unclear and need further examination.
