GASTRIC ADENOCARCINOMA AND HELICOBACTER-PYLORI INFECTION
GASTRIC ADENOCARCINOMA AND HELICOBACTER-PYLORI INFECTION
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DOI：
10.1093/jnci/83.23.1734
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发表时间：
1991-12-04
期刊：
影响因子：
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通讯作者：
BLASER, MJ
中科院分区：
文献类型：
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作者：
TALLEY, NJ;ZINSMEISTER, AR;BLASER, MJ
幽门螺杆菌感染被认为与慢性胃炎有因果关系，也可能与胃癌风险增加有关。为了确定与胃癌是否存在相关性，我们回顾性评估了69例组织学证实的胃腺癌患者（32例贲门癌和37例其他部位癌）和218例非胃癌、其他胃癌或良性胃肿瘤患者的血清样本。将这些样本与252名无癌症对照受试者的样本进行比较，该组包括76名无症状志愿者和176名非恶性疾病患者。从手术前的癌症患者和无癌对照组中收集的血清样品进行了H. pylori的IgG酶联免疫吸附试验。H.使用多变量逻辑回归分析来估计病例患者相对于对照受试者的幽门螺杆菌感染，以调整潜在的混杂变量。螺杆菌抗体pylori在非贲门部胃癌中检出率为65%，而在贲门部胃癌中检出率仅为38%。H. pylori感染与非贲门胃癌的危险性（OR = 2.67; 99%可信区间= 1.01-7.06）。在非贲门癌患者亚组中，肠道非贲门癌患者与弥漫性组织学类型非贲门癌患者相比，H的风险更高，但统计学上不显着。幽门感染我们的研究结果支持H. pylori感染与非贲门胃腺癌的发生
Helicobacter pylori infection, thought to be causally related to chronic gastritis, may also be associated with an increased risk of gastric cancer. To determine whether an association with gastric cancer does exist, we retrospectively evaluated serum samples from 69 patients with histologically confirmed gastric adenocarcinoma (32 with cancer at the cardia and 37 with cancer at other sites) and from 218 patients with one of three categories of nongastric cancers, with other gastric cancers, or with benign gastric neoplasms. These samples were compared with samples from 252 cancer-free control subjects, a group comprising 76 asymptomatic volunteers and 176 persons with nonmalignant disorders. Serum samples collected from cancer patients prior to surgery and from cancer-free controls were tested for antibodies to H. pylori by using a highly sensitive and specific IgG enzyme-linked immunosorbent assay. The risk of H. pylori infection in the case patients relative to the control subjects was estimated with the use of multivariate logistic regression analysis to adjust for potential confounding variables. Antibodies to H. pylori were detected in 65% of the patients with noncardia gastric cancer but in only 38% of the patients with gastric cancer located at the cardia. A significant association was found between H. pylori infection and noncardia gastric cancer (odds ratio = 2.67; 99% confidence interval = 1.01-7.06). Within the subset of patients with noncardia gastric cancer, a statistically nonsignificant tendency existed for those with the intestinal versus the diffuse histologic type of noncardia gastric cancer to have a higher risk of H. pylori infection. Our results support the hypothesis of a relationship between H. pylori infection and the development of noncardia gastric adenocarcinoma.