Comparison of tumor histology to dynamic contrast enhanced magnetic resonance imaging-based physiological estimates
Comparison of tumor histology to dynamic contrast enhanced magnetic resonance imaging-based physiological estimates
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DOI：
10.1016/j.mri.2008.02.015
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发表时间：
2008-11-01
影响因子：
2.5
通讯作者：
Wiener, Erik C.
中科院分区：
文献类型：
--
作者：
Aref, Michael;Chaudhari, Amir R.;Wiener, Erik C.
目的：本研究的目的是将组织学确定的细胞结构和细胞外空间与基于动态对比增强磁共振成像 (DCE MRI) 的二室模型参数图进行比较，这些参数描述肿瘤造影剂外渗，特别是肿瘤血管外细胞外空间 (EES) 体积分数 (v(e))、肿瘤血浆体积分数 (v(p)) 以及肿瘤血浆和间质之间的体积归一化造影剂转移率(K-TRANS/V-T) 材料和方法：从分辨率为 469、938 和 2500 μm 的二亚乙基三胺五乙酸钆 DCE T-1 加权梯度回波图像估计获得的 v(e)、v(p) 和 K-TRANS/V-T 图。将这些参数图在每个分辨率下与组织学确定的肿瘤类型进行比较，并将高分辨率 469-μm 图与使用 Otsu 方法和颜色阈值方法进行自动细胞计数进行比较，以估计细胞内（V-细胞内）和细胞外（V-细胞外）空间分数。结果：在 469 和 938μm 分辨率下从每个肿瘤获得的前五个 K-TRANS/V-T 值与下午 2500 点获得的数据 (P .05)。基于 DCE MRI 的 K-TRANS/V-T 估计与组织学确定的细胞结构没有统计相关性。结论：肿瘤生理学的 DCE MRI 估计是肿瘤组织学特征的有限表示。 DCE MRI 和显微镜分析测量的细胞外间隙在统计上相似。 DCE MRI 的肿瘤分型取决于空间分辨率，因为较低的分辨率平均了对基于体素的 K-TRANS/V-T 估计的贡献。因此，适当的分辨率窗口对于 DCE MRI 肿瘤诊断至关重要。在此分辨率窗口内，顶部 K-TRANS/V-T 值以及相应的 v(e) 可诊断本研究中分析的肿瘤类型。 (c) 2008 年，爱思唯尔公司出版。
Purpose: The purpose of this study was to compare histologically determined cellularity and extracellular space to dynamic contrast-enhanced magnetic resonance imaging (DCE MRI)-based maps of a two-compartment model's parameters describing tumor contrast agent extravasation, specifically tumor extravascular extracellular space (EES) volume fraction (v(e)), tumor plasma volume fraction (v(p)) and volume-normalized contrast agent transfer rate between tumor plasma and interstitium (K-TRANS/V-T)Materials and Methods: Obtained v(e), v(p) and K-TRANS/V-T maps were estimated from gadolinium diethylenetriamine penta-acetic acid DCE T-1-weighted gradient-echo images at resolutions of 469, 938 and 2500 mu m. These parameter maps were compared at each resolution to histologically determined tumor type, and the high-resolution 469-mu m maps were compared with automated cell counting using Otsu's method and a color-thresholding method for estimated intracellular (V-intracellular) and extracellular (V-extracellular) space fractions.Results: The top five K-TRANS/V-T values obtained from each tumor at 469 and 938 mu m resolutions are significantly different from those obtained at 2500 pm (P .05). DCE MRI-based K-TRANS/V-T estimates are not statistically correlated with histologically determined cellularity.Conclusion: DCE MRI estimates of tumor physiology are a limited representation Of tumor histological features. Extracellular spaces measured by both DCE M RI and microscopic analysis are statistically similar. Tumor typing by DCE MRI is spatial resolution dependent, as lower resolutions average out contributions to voxel-based estimates of K-TRANS/V-T. Thus, an appropriate resolution window is essential for DCE MRI tumor diagnosis. Within this resolution window, the top K-TRANS/V-T values with corresponding v(e) are diagnostic for the tumor types analyzed in this study. (c) 2008 Published by Elsevier Inc.