What we don't know can hurt us: Nonresponse bias assessment in birth defects research.
What we don't know can hurt us: Nonresponse bias assessment in birth defects research.
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我们不知道的事情可能会伤害我们：出生缺陷研究中的无反应偏差评估。
DOI：
10.1002/bdra.23408
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Grosse,ScottD
中科院分区：
文献类型：
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作者：
Strassle,PaulaD;Cassell,CynthiaH;Shapira,StuartK;Tinker,SarahC;Meyer,RobertE;Grosse,ScottD
无回答偏倚评估是调查研究中评估由于不完全参与而导致的潜在偏倚的一个重要但未得到充分利用的工具。这项研究说明了一个无反应偏见的敏感性评估使用的调查，感知障碍，以照顾儿童orofacial裂缝在北卡罗来纳州。METHODS儿童出生在北卡罗来纳州之间的2001年和2004年的orofacial裂缝有资格列入。可获得所有合格受试者的生命统计数据，包括孕产妇和儿童特征。缺失的“响应”，从非参与者填补使用的假设的基础上的分布的响应，调查方法（邮件或电话），和参与者的母亲demographics. NoteTSOverall，245的475名受试者（51.6%）回答了邮件或电话调查。25.0%的参与者报告成本是护理的障碍。当按调查类型分层时，28.3%的邮件受访者和17.2%的电话受访者表示成本是一个障碍。在各种假设下，经偏倚调整的成本作为治疗障碍的估计患病率范围为16.1%至30.0%。产妇的年龄，教育，种族，婚姻状况在出生时没有相关的主题报告成本作为barrier. CONCLUSION作为调查的响应率继续下降，评估潜在影响的无响应偏见的重要性已变得更加关键。出生缺陷研究特别有利于无应答偏倚分析，特别是当使用出生缺陷登记和出生证明记录时。未来使用基于人群的监测数据和不完全参与的出生缺陷研究可以从这种类型的无应答偏倚评估中受益。出生缺陷研究（A部分）103：603-609，2015年。© 2015 Wiley Periodicals，Inc.
BACKGROUNDNonresponse bias assessment is an important and underutilized tool in survey research to assess potential bias due to incomplete participation. This study illustrates a nonresponse bias sensitivity assessment using a survey on perceived barriers to care for children with orofacial clefts in North Carolina.METHODSChildren born in North Carolina between 2001 and 2004 with an orofacial cleft were eligible for inclusion. Vital statistics data, including maternal and child characteristics, were available on all eligible subjects. Missing ‘responses’ from nonparticipants were imputed using assumptions based on the distribution of responses, survey method (mail or phone), and participant maternal demographics.RESULTSOverall, 245 of 475 subjects (51.6%) responded to either a mail or phone survey. Cost as a barrier to care was reported by 25.0% of participants. When stratified by survey type, 28.3% of mail respondents and 17.2% of phone respondents reported cost as a barrier. Under various assumptions, the bias‐adjusted estimated prevalence of cost as barrier to care ranged from 16.1% to 30.0%. Maternal age, education, race, and marital status at time of birth were not associated with subjects reporting cost as a barrier.CONCLUSIONAs survey response rates continue to decline, the importance of assessing the potential impact of nonresponse bias has become more critical. Birth defects research is particularly conducive to nonresponse bias analysis, especially when birth defect registries and birth certificate records are used. Future birth defect studies which use population‐based surveillance data and have incomplete participation could benefit from this type of nonresponse bias assessment. Birth Defects Research (Part A) 103:603–609, 2015. © 2015 Wiley Periodicals, Inc.