Uterine leukocytes and decidualization
Uterine leukocytes and decidualization
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DOI：
10.1093/humupd/6.1.28
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发表时间：
2000-01-01
影响因子：
13.3
通讯作者：
King, A
中科院分区：
文献类型：
--
作者：
King, A
子宫内膜向蜕膜的转化是正常着床和妊娠的基本特征，与异常的白细胞群、子宫自然杀伤（NK）细胞和蜕膜化的发生密切相关。这些子宫NK细胞在超微结构上与基质细胞紧密接触，也可以看到环绕血管和腺体。子宫NK细胞在分泌后期和早期蜕膜中可能在启动和维持蜕膜化中起重要作用。相反，子宫NK细胞的死亡可能是月经期子宫内膜破裂的早期事件。着床和月经之间的时期（黄体生成素激增后7-14天）是着床特别脆弱的时间，在这篇综述中，子宫白细胞可能会影响中期至晚期分泌期子宫内膜必须做出的决定，即蜕膜化或经历月经。
The transformation of endometrium into decidua is an essential feature of normal implantation and pregnancy, There is a close association with an unusual leukocyte population, uterine natural killer (NK) cells, and onset of decidualization. These uterine NK cells are seen in close contact with stromal cells ultrastructurally and are also seen encircling vessels and glands. The possibility that uterine NK cells in the late secretory phase and in early decidua may be important in initiating and maintaining decidualization is raised. In contrast, the death of uterine NK cells could be an early event in the onset of endometrial breakdown at menstruation. The period between implantation and menstruation (7-14 days after luteinizing hormone surge) is the time when implantation is known to be particularly vulnerable, In this review, the possibility that uterine leukocytes might influence the critical decision that the mid- to late secretory endometrium must make either to decidualize or to undergo menstruation is explored.