The genome organization of STLV-3 is similar to that of the AIDS virus except for a truncated transmembrane protein.
The genome organization of STLV-3 is similar to that of the AIDS virus except for a truncated transmembrane protein.
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除了截短的跨膜蛋白外，STLV-3 的基因组结构与艾滋病病毒的基因组结构相似。
DOI：
10.1016/0092-8674(87)90283-2
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发表时间：
1987
期刊：
影响因子：
64.5
通讯作者：
Mullins,JI
中科院分区：
文献类型：
--
作者：
Hirsch,V;Riedel,N;Mullins,JI
非洲绿色猴嗜T淋巴细胞病毒3型（STLV-3agm）基因组3 '端的核苷酸序列分析表明，它具有与人类免疫缺陷病毒（HIV-1）相同的基因组结构。两种病毒的达特和art/trs开放阅读框（orf）具有较强的氨基酸同源性和相似的预测蛋白质结构的短片段。3 'orf和另一个csorf的强保守性（没有鉴定出蛋白质产物）表明它们都编码对这些病毒的生命周期重要的蛋白质。STLV-3和HIV-1的胞外糖蛋白具有相似的骨架结构，在HIV-1蛋白的恒定区有50%~ 55%的氨基酸同源性。结构组织中最明显的偏离是两个STLV-3agm克隆和一个具有生物活性的非细胞病变HTLV-4克隆中跨膜糖蛋白的截短。
Nucleotide sequence analysis of the 3’portion of the genome of simian T-lymphotropic virus type 3 from African green monkeys (STLV-3agm) reveals that it has the same general genome structure as the human immunodeficiency virus (HIV-l), the etlologlc agent of AIDS. Short segments of strong amino acid homology and similar predicted protein structure characterize the tat and art/trs open reading frames (orf) of both viruses Strong conservation of 3’orf and of another, csorf, for which no protein product has been identified suggests that they both encode proteins important to the life cycle of these viruses. The extracellular glycoproteins of STLV-3 and HIV-1 share a similar backbone structure and 50%~ 55% amino acid homology in constant domains of the HIV-1 protein. The most evident departure in structural organization is truncation of the transmembrane glycoproteins In two STLV-3agm clones and a biologically active, noncytopathic clone of HTLV-4.