Assessment of vasoactive agents and vascular aging by the second derivative of photoplethysmogram waveform
Assessment of vasoactive agents and vascular aging by the second derivative of photoplethysmogram waveform
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DOI：
10.1161/01.hyp.32.2.365
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发表时间：
1998-08-01
期刊：
影响因子：
8.3
通讯作者：
Ibukiyama, C
中科院分区：
文献类型：
--
作者：
Takazawa, K;Tanaka, N;Ibukiyama, C
为了评价指尖光电容积描记图波形的二阶导数的临床应用，我们进行了给药研究（研究1）和流行病学研究（研究2）。在研究1中，在39例患者中同时记录了升主动脉压和指尖光电容积描记图及其二阶导数，平均+/-SD年龄为54+/-11岁。增大指数定义为脉搏收缩晚期峰值与收缩早期峰值的高度之比。二阶导数包括收缩期的a、B、c和d波以及舒张期的e波。注射2.5 μ g血管紧张素后升主动脉压从126/74升高至160/91 mm Hg，舌下含服0.3 mg硝酸甘油后降至111/73 mm Hg。d/a，即d波高度与a波高度的比值，在血管紧张素治疗后从-0.40+/-0.13降至-0.62+/-0.19，在硝酸甘油治疗后增至-0.25+/-0.12（P
To evaluate the clinical application of the second derivative of the fingertip photoplethysmogram waveform, we performed drug administration studies (study 1) and epidemiological studies (study 2). In study 1, ascending aortic pressure was recorded simultaneously with the fingertip photoplethysmogram and its second derivative in 39 patients with a mean+/-SD age of 54+/-11 years. The augmentation index was defined as the ratio of the height of the late systolic peak to that of the early systolic peak in the pulse. The second derivative consists of an a, b, c, and d wave in systole and an e wave in diastole. Ascending aortic pressure increased after injection of 2.5 mu g angiotensin from 126/74 to 160/91 mm Hg and decreased after 0.3 mg sublingual nitroglycerin to 111/73 mm Hg. The d/a, the ratio of the height of the d wave to that of the a wave, decreased after angiotensin from -0.40+/-0.13 to -0.62+/-0.19 and increased after nitroglycerin to -0.25+/-0.12 (P