Hepatic fatty acid oxidation enzyme activities are stimulated in rats fed the brown seaweed, Undaria pinnatifida (wakame)
Hepatic fatty acid oxidation enzyme activities are stimulated in rats fed the brown seaweed, Undaria pinnatifida (wakame)
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DOI：
10.1093/jn/129.1.146
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发表时间：
1999-01-01
影响因子：
4.2
通讯作者：
Saito, H
中科院分区：
文献类型：
--
作者：
Murata, M;Ishihara, K;Saito, H
比较了饲喂不同比例褐藻干粉的大鼠肝脏中与脂肪酸合成和氧化有关的酶活性。大鼠分别饲喂含有0、0.5、1.0、2.0、5.0和10g/100g的干杏仁粉的饲料。实验饮食进行了调整，以提供稳定的大部分营养素，但矿物质浓度并未标准化。饲喂21天后，饲喂至少2%WAKAME饲料的大鼠血清和肝脏三酰甘油水平显著低于对照组。饲喂5%和10%WAKAME饲料的大鼠葡萄糖-6-磷酸脱氢酶活性显著低于对照组。与之相反，10%的wakame饲料提高了与P氧化途径有关的酶的活性，包括肝肉碱棕榈酰基转移酶、酰辅酶A脱氢酶、酰辅酶A氧化酶、烯醇酰辅酶A水合酶和2，4-二烯酰辅酶A还原酶。喂食5%WAKAME的大鼠也发现了一些差异。这些结果表明，肝脏中参与脂肪酸代谢的酶活性的变化是饮食WAKAME降低血清三酰甘油效果的原因。因此，芒果可能是一种预防高脂血症的食物。
The activities of hepatic enzymes involved in fatty acid synthesis and oxidation were compared in rats fed diets containing different proportions of dried powder of the brown seaweed, Undaria pinnatifida (wakame). Rats were fed diets containing 0, 0.5, 1.0, 2.0, 5.0 and 10 g/100 g of dried wakame powder. Experimental diets were adjusted to provide consistent amounts of most nutrients, but mineral concentrations were not standardized. After the 21-d feeding period, serum and liver triacylglycerol levels in rats fed diets in which wakame constituted at least 2% were significantly lower than those in rats fed the control diet. The activity of glucose-6-phosphate dehydrogenase was significantly lower in rats fed the 5 and 10% wakame diets than in rats fed the control diet. In contrast, 10% wakame diet increased activities of enzymes involved in the P-oxidation pathway including hepatic carnitine palmitoyltransferase, acyl-CoA dehydrogenase, acyl-CoA oxidase, enoyl-CoA hydratase and 2,4-dienoyl-CoA reductase. Some differences were detected in rats fed 5% wakame as well. These results suggest that alterations of the activities of enzymes involved in fatty acid metabolism in the liver are responsible for the serum triacylglycerol-lowering effect of dietary wakame. Thus, wakame may be useful as a food to prevent hyperlipidemia.