Evidence for a halothane-induced reduction in maximal calcium-activated force in mammalian myocardium.
Evidence for a halothane-induced reduction in maximal calcium-activated force in mammalian myocardium.
复制标题
氟烷诱导哺乳动物心肌最大钙激活力降低的证据。
DOI：
10.1007/978-1-4684-5979-1_17
复制
发表时间：
1991
影响因子：
--
通讯作者：
Blanck,TJ
中科院分区：
文献类型：
--
作者：
Berman,MR;Casella,ES;Blanck,TJ
除全身麻醉作用外，已知的卤化挥发性麻醉剂(如氟烷、安氟醚、异氟烷)可显著抑制心脏收缩能力。在20世纪60年代末，S、Goldberg和Ullrick1报道了氟烷(由校准的蒸发器提供)在0.1%到2.35%的范围内对抽动力的剂量依赖性和可逆性抑制作用。他们争辩说“…氟烷似乎主要通过降低活性状态的强度来发挥其心脏作用。…“在一项关于几种普通麻醉剂对心脏收缩能力影响的比较研究中，Brown和Crout2报告了氟烷和甲氧氟烷的类似结果。他们还表明，这些药物通过减少心肌的活跃状态来发挥其心脏抑制作用。虽然“活动状态”的概念已不再有用，但已知它与钙瞬变有关；即电刺激后细胞内游离钙浓度的快速上升和下降。
In addition to their general anesthetic effects, the halogenated volatile anesthetics (e.g., halothane, enflurane, isoflurane) are known to significantly depress cardiac contractility. In the late 1960’s, Goldberg and Ullrick1reported a dose-dependent and reversible depression of twitch force by halothane (as delivered by a calibrated vaporizer) in the range of 0.1% to 2.35%. They argued that “… halothane seems to exert its cardiac effects primarily by decreasing the intensity of the active state. …” In a comparative study of the effects of several general anesthetic agents on cardiac contractility, Brown and Crout2reported similar results for halothane as well as for methoxyflurane. They, too, suggested that these agents exerted their cardio-depressive effectsviaa diminution of the active state of cardiac muscle. Although the concept of “active state” is no longer useful, it is known to be associated with the calcium transient; that is, the rapid rise and fall of intracellular free calcium concentration seen subsequent to electrical stimulation.