Role of H3K9 demethylases in DNA double-strand break repair.
Role of H3K9 demethylases in DNA double-strand break repair.
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DOI：
10.46439/cancerbiology.1.003
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Qi, Jianfei
中科院分区：
文献类型：
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作者：
Jeon, Hee-Young;Hussain, Arif;Qi, Jianfei
H3 K9去甲基化酶可以去除组蛋白上抑制性的H3 K9甲基化标记，从而改变细胞的染色质结构、基因转录和表观遗传状态。通过抵消H3 K9甲基转移酶的功能，H3 K9脱甲基酶已被证明在许多生物过程中发挥重要作用，包括疾病如癌症。最近的证据表明，一些H3 K9脱甲基酶在通过同源重组（HR）和/或非同源末端连接（NHEJ）途径修复DNA双链断裂（DSB）中起关键作用。从机制上讲，H3 K9脱甲基酶可以上调DNA修复因子的表达。它们也可以被募集到DNA损伤位点并调节DNA修复因子的募集或功能。在此，我们将讨论H3 K9去甲基化酶在DSB修复调控中的作用和机制。
H3K9 demethylases can remove the repressive H3K9 methylation marks on histones to alter chromatin structure, gene transcription and epigenetic state of cells. By counteracting the function of H3K9 methyltransferases, H3K9 demethylases have been shown to play an important role in numerous biological processes, including diseases such as cancer. Recent evidence points to a key role for some H3K9 demethylases in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR) and/or non-homologous end joining (NHEJ) pathways. Mechanistically, H3K9 demethylases can upregulate the expression of DNA repair factors. They can also be recruited to the DNA damage sites and regulate the recruitment or function of DNA repair factors. Here, we will discuss the role and mechanisms of H3K9 demethylases in the regulation of DSB repair.