Blood vessel contributions to retinal nerve fiber layer thickness profiles measured with optical coherence tomography.
Blood vessel contributions to retinal nerve fiber layer thickness profiles measured with optical coherence tomography.
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DOI：
10.1097/ijg.0b013e3181629a02
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发表时间：
2008-10
影响因子：
2
通讯作者：
Liebmann JM
中科院分区：
文献类型：
--
作者：
Hood DC;Fortune B;Arthur SN;Xing D;Salant JA;Ritch R;Liebmann JM
目的探讨视网膜血管对光学相干断层扫描（OCT）测量的视网膜神经纤维层（RNFL）厚度个体差异的影响。OCT测量16名对照者和16名患者的RNFL厚度分布。这些患者患有晚期青光眼，定义为椎间盘外观异常、视野异常和平均视野偏差小于-10 dB。总体而言，OCT RNFL厚度曲线显示4个局部最大值，上级和下级区域的峰值振幅出现在颞（视乳头周围）盘区域。个体之间在这些最大值的位置上存在相当大的差异。然而，4个最大值通常落在主要BV上或附近，其中颞峰和下峰几乎总是与上级和下级静脉和动脉的主要颞支相关。在患者严重损失的半野中（平均视野偏差低于-20 dB），与主要BV相关的信号大约为100至150 µm。对照组RNFL分布的局部峰值的变化与上级和下级静脉和动脉的主要颞支的位置密切相关。这种对应关系部分是由于BV对OCT RNFL形状的直接贡献，部分是由于BV沿轴突的致密区域沿着发展的事实。虽然估计总体BV贡献相对较小，约占对照组总视乳头周围RNFL厚度的13%，但其贡献在局部占很大比例，并随着疾病进展而增加。
To understand better the influence of retinal blood vessels (BVs) on the interindividual variation in the retinal nerve fiber layer (RNFL) thickness measured with optical coherence tomography (OCT). RNFL thickness profiles were measured by OCT in 16 control individuals and 16 patients. The patients had advanced glaucoma defined by abnormal disc appearance, abnormal visual fields, and a mean visual field deviation worse than − 10 dB. In general, the OCT RNFL thickness profiles showed 4 local maxima, with the peak amplitudes in the superior and inferior regions occurring in the temporal (peripapillary) disc region. There was considerable variability among individuals in the location of these maxima. However, the 4 maxima typically fell on, or near, a major BV with the temporal and inferior peaks nearly always associated with the main temporal branches of the superior and inferior veins and arteries. In the patients’ hemifields with severe loss (mean visual field deviation worse than − 20 dB), the signals associated with the major BVs were in the order of 100 to 150 µm. The variation in the local peaks of the RNFL profiles of controls correlates well with the location of the main temporal branches of the superior and inferior veins and arteries. This correspondence is, in part, due to a direct BV contribution to the shape of the OCT RNFL and, in part, due to the fact that BVs develop along the densest regions of axons. Although the overall BV contribution was estimated to be relatively modest, roughly 13% of the total peripapillary RNFL thickness in controls, their contribution represents a substantial portion locally and increases in importance with disease progression.