Prognostic Significance of Serum Cysteine-Rich Protein 61 in Patients with Acute Heart Failure
Prognostic Significance of Serum Cysteine-Rich Protein 61 in Patients with Acute Heart Failure
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血清富含半胱氨酸蛋白 61 对急性心力衰竭患者的预后意义。
DOI：
10.1159/000491984
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发表时间：
2018-01-01
影响因子：
--
通讯作者：
Liu, Chen
中科院分区：
文献类型：
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作者：
Zhao, Jingjing;Zhang, Chongyu;Liu, Chen
背景/目的：富含 Cyr61 半胱氨酸的蛋白 61 (CCN1/CYR61) 是一种参与纤维发生调节的多功能基质细胞蛋白。动物实验证明CCN1可以抑制心脏肥大时的心肌纤维化。然而，尚未进行研究评估血清CCN1与急性心力衰竭（AHF）预后之间的关系。方法：检测183例AHF患者血清CCN1水平，并对患者进行6个月随访。评估了 CCN1 水平与一些临床协变量，特别是左心室射血分数 (LVEF)、估计肾小球滤过率 (eGFR)、心房颤动和年龄之间的关联。对 AHF 患者进行了 6 个月的随访。终点是全因死亡率。采用Kaplan-Meier曲线分析和多变量Cox比例风险分析来评估CCN1的预后能力。我们使用校准、区分和重新分类来评估添加 CCN1 的死亡风险预测。结果：与无 AHF 的个体相比，AHF 患者的血清 CCN1 浓度显着升高（237 pg/ml vs. 124.8 pg/ml，p
Background/Aims: Cyr61-cysteine-rich protein 61 (CCN1/CYR61) is a multifunctional matricellular protein involved in the regulation of fibrogenesis. Animal experiments have demonstrated that CCN1 can inhibit cardiac fibrosis in cardiac hypertrophy. However, no study has been conducted to assess the relation between serum CCN1 and prognosis of acute heart failure (AHF). Methods: We measured the serum CCN1 levels of 183 patients with AHF, and the patients were followed up for 6 months. The associations between CCN1 levels and some clinical covariates, especially left ventricular ejection fraction (LVEF), estimated glomerular filtration rate (eGFR), atrial fibrillation and age, were estimated. The AHF patients were followed up for 6 months. The endpoint was all-cause mortality. Kaplan-Meier curve analysis and multivariable Cox proportional hazards analysis were employed to evaluate the prognostic ability of CCN1. We used calibration, discrimination and reclassification to assess the mortality risk prediction of adding CCN1. Results: Serum CCN1 concentrations in AHF patients were significantly increased compared with those in individuals without AHF (237 pg/ml vs. 124.8 pg/ml, p