COCAINE PLASMA CONCENTRATION - RELATION TO PHYSIOLOGICAL AND SUBJECTIVE EFFECTS IN HUMANS
COCAINE PLASMA CONCENTRATION - RELATION TO PHYSIOLOGICAL AND SUBJECTIVE EFFECTS IN HUMANS
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DOI：
10.1126/science.694530
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发表时间：
1978-01-01
期刊：
影响因子：
56.9
通讯作者：
DAVIS, JM
中科院分区：
文献类型：
--
作者：
JAVAID, JI;FISCHMAN, MW;DAVIS, JM
有可卡因使用史的志愿者接受盐酸可卡因静脉注射。或者鼻腔注射。峰值血药浓度、生理反应和主观反应与给药剂量呈正相关。静脉注射后可卡因消失率。服药与生理和主观药物效应的下降是平行的。在鼻腔给药后，血液水平在相当长的一段时间内保持在较高水平。
Volunteer subjects with previous histories of cocaine use were administered cocaine hydrochloride i.v. or intranasally. There was a positive relationship between peak plasma concentration, physiological and subjective responses, and dose administered. The rate of cocaine disappearance after i.v. administration paralleled the drop in physiological and subjective drug effects. After intranasal administration, blood levels remained elevated for a considerably longer period.