Comparison of early systolic and early diastolic regional function during regional ischemia in a chronically instrumented canine model.
Comparison of early systolic and early diastolic regional function during regional ischemia in a chronically instrumented canine model.
复制标题
长期仪器犬模型局部缺血期间早期收缩和早期舒张区域功能的比较。
DOI：
10.1016/s0735-1097(83)80162-4
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发表时间：
1983
影响因子：
24
通讯作者：
Gould,KL
中科院分区：
文献类型：
--
作者：
Smalling,RW;Kelley,KO;Kirkeeide,RL;Gould,KL
据报道，静息状态下收缩和舒张期早期(前1/3)的左心功能受抑是静息状态下整体功能正常的患者冠状动脉病变的敏感指标。为了探讨这些发现的可能机制，对11只狗进行了左回旋支和左前降支分布的节段性功能声学测微仪、回旋支冠状动脉血流探头和袖带封堵器、主动脉血流探头和心室压力传感器的慢性测量。在对照状态和旋支动脉血流分级减少的情况下，测量收缩和舒张期前1/3的节段功能百分比。左前降支分布的代偿性增大缩短部分抵消了回旋支分布缺血时早期收缩功能的显著下降。回旋支分布缺血时，收缩延长至舒张期，表现为舒张性受损。同时，在左前降支分布中，有微小的代偿性增强的松弛。这些结果表明，缺血节段的早期收缩功能障碍可以被非缺血节段的功能增强所抵消，使整体收缩功能的变化即使有的话，也是最小的。缺血节段的早期舒张期功能障碍比非缺血区的代偿性改变多二到四倍。因此，早期舒张期功能指数可能比早期收缩功能指数更敏感地反映静息状态的缺血。
Depressed left ventricular function during the early part (first third) of both systole and diastole in the resting state have been reported to be sensitive indicators of coronary artery disease in patients with normal global function at rest. To evaluate the possible mechanisms of these findings, 11 dogs were chronically instrumented with segmental function sonomicrometers in the left circumflex and left anterior descending coronary artery distribution, circumflex coronary flow probes and cuff occluders, aortic flow probes and ventricular pressure transducers. Percent segmental function during the first third of systole and diastole was measured in the control state and with graded circumflex artery flow reductions. Significant decreases in early systolic function with ischemia in the circumflex artery distribution were partially offset by compensatory augmented shortening in the left anterior descending artery distribution. With ischemia in the circumflex distribution, there was prolonged contraction into diastole manifested as impaired relaxation. Simultaneously, in the left anterior descending artery distribution, there was minimal compensatory enhanced relaxation.These results suggest that early systolic dysfunction in ischemic segments may be offset by enhanced function in nonischemic segments, rendering minimal, if any, change in global systolic function. Early diastolic dysfunction in ischemic segments exceeds compensatory changes in nonischemic areas by two-to four-fold. Hence, early diastolic functional indexes may be more sensitive indicators of ischemia at rest than early systolic functional indexes.