Early glottic carcinoma: Treatment according patient's preference?
Early glottic carcinoma: Treatment according patient's preference?
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DOI：
10.1002/hed.10323
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发表时间：
2003-12-01
影响因子：
2.9
通讯作者：
Schmid, S
中科院分区：
文献类型：
--
作者：
Stoeckli, SJ;Schnieper, I;Schmid, S
背景。以病人为本，分析我院早期（I期和11期）声门癌的治疗结果。在诊断检查和多学科咨询后，根据患者的喜好选择放射治疗或CO2激光手术。65例患者接受激光手术，75例接受放射治疗。对于T1肿瘤，激光手术和放疗后的5年总生存率、疾病特异性生存率和初始局部控制率具有可比性（OS, 85% vs 88%； DSS, 96% vs 93%； LCR, 86% vs 85%）。相比之下，手术后T2肿瘤的初始局部控制明显更有利（OS， 83%对78%；DSS， 83%对88%；LCR， 89%对67%）。T1肿瘤和T2肿瘤术后喉保存率分别为96%和82%和89%和77%。根据患者的喜好选择治疗方式，可使T1肿瘤的疾病得到相当的控制。术后T2肿瘤的初始局部控制明显改善。在这两个阶段，激光手术保证了更好的喉保存率。(C) 2003 Wiley期刊有限公司
Background. To analyze the results in early (stage I and 11) glottic carcinoma of a single institution with a patient-oriented concept.Methods. After diagnostic workup and multidisciplinary counseling, either radiotherapy or CO2 laser surgery was chosen with respect to the patient's preference.Results. Sixty-five patients underwent laser surgery and 75 had radiotherapy. For T1 tumors, the 5-year overall survival, disease-specific survival, and initial local control rate after laser surgery and radiotherapy were comparable (OS, 85% vs 88%; DSS, 96% vs 93%; LCR, 86% vs 85%). In contrast, initial local control for T2 tumors was significantly more favorable after surgery (OS, 83% vs 78%; DSS, 83% vs 88%; LCR, 89% vs 67%). Larynx preservation was significantly higher after surgery in T1 tumors (96% vs 82%) and in T2 tumors (89% vs 77%).Conclusions. Selection of the treatment modality according to patient's preference results in a comparable control of disease for T1 tumors. The initial local control for T2 tumors is significantly better after surgery. In both stages laser surgery warrants a better larynx preservation rate. (C) 2003 Wiley Periodicals, Inc.