In vitro degradation of polyglycolic acid synthesized by a one-step reaction
In vitro degradation of polyglycolic acid synthesized by a one-step reaction
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DOI：
10.1515/polyeng-2014-0005
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发表时间：
2014-09
影响因子：
2
通讯作者：
Siye Tang;Gui-Lian Li;Rui Zhang;Le-Ping Huang;H. Tang
中科院分区：
文献类型：
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作者：
Siye Tang;Gui-Lian Li;Rui Zhang;Le-Ping Huang;H. Tang
摘要 以氯乙酸和三乙胺在四氢呋喃中一步反应合成聚乙醇酸。对聚乙醇酸的水解降解进行了研究。在磷酸盐缓冲液中研究体外降解。使用傅里叶变换红外光谱、重量损失、熔点、X射线粉末衍射、pH值和扫描电子显微镜测量来检查降解过程。聚乙醇酸在体外降解过程中化学结构变化较小。降解发生时，在降解初期，失重增加，熔点降低，结晶度增加，随后又降低。第六周后熔点突然下降。这表明降解程度突然增加，即聚乙醇酸的分子量应突然降低。在体外降解过程中，缓冲溶液的pH值迅速下降并随着时间的推移而降低。 pH较低表明一步反应合成的聚乙醇酸的分子量应该较低，这可能使聚乙醇酸容易降解。随着降解时间的增加，聚乙醇酸样品的表面高度降解，表面孔隙率增加。
Abstract Polyglycolic acid was synthesized by a one-step reaction of chloroacetic acid and triethylamine in tetrahydrofuran. The hydrolytic degradation of polyglycolic acid has been investigated. The in vitro degradation was investigated in a saline phosphate buffer. The degradation process was examined using Fourier transform infrared spectroscopy spectrum, weight loss, melting point, X-ray powder diffraction, pH, and scanning electron microscopy measurements. The chemical structure of polyglycolic acid has a small change during in vitro degradation. Degradation occurred with an increase in weight loss, a decrease in melting point, an increase in crystallinity during the initial degradation period and then a decrease afterwards. The melting point fell abruptly after the sixth week. This indicates that the degradation degree increased suddenly, i.e., the molecular weight of polyglycolic acid should decrease abruptly. The pH of the buffer solution fell quickly and decreased with time during in vitro degradation. The lower pH indicates that the molecular weight of polyglycolic acid synthesized by a one-step reaction should be low, and this may enable polyglycolic acid to degrade easily. As the degradation time increased, the surfaces of polyglycolic acid samples were highly degraded, and the surface porosity increased.