The corpus callosum during postnatal undernourishment and recovery: a morphometric analysis of myelin and axon relationships.
The corpus callosum during postnatal undernourishment and recovery: a morphometric analysis of myelin and axon relationships.
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产后营养不良和恢复期间的胼胝体：髓磷脂和轴突关系的形态测量分析。
DOI：
10.1016/0006-8993(85)91321-6
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发表时间：
1985
期刊：
影响因子：
2.9
通讯作者：
Samorajski,T
中科院分区：
文献类型：
--
作者：
Wiggins,RC;Bissell,AC;Durham,L;Samorajski,T
本研究旨在比较营养不良和营养良好的发育大鼠和营养恢复两周的大鼠髓鞘和轴突之间的形态计量学关系。尽管本研究中采用的取样技术并非专门设计用于比较试验人群和对照人群中的有髓纤维数量，但我们确实观察到了有髓纤维数量减少的趋势。所有有髓轴突的平均髓鞘板层的平均数在对照组和试验组中没有差异。然而，回归分析的轴突大小的髓鞘laminates的数量显示显着差异，从正常的21日龄营养不良大鼠。对于任何大小的胼胝体轴突，在营养不良的大鼠中髓鞘层太少。到35天龄，在相对较小的纤维中观察到部分恢复，但在较大尺寸的纤维中没有观察到恢复。有髓纤维轴突周长频率分布的比较显示，平均轴突口径增加。计算表明，尽管营养不良并没有改变轴突的平均数量，但轴突本身的大小增加了约10%。这个意想不到的结果表明，正常情况下，髓鞘板层的数量的关系被出生后的营养缺乏改变，相对较大的轴突口径不产生在ensheating少突胶质细胞的髓鞘层的任何补偿性增加。
This study was designed to compare morphometric relationships between myelin lamellae and axons in undernourished and well nourished developing rats, and in rats nutritionally rehabilitated for two weeks. Although sampling techniques employed in this study were not specifically designed to compare numbers of myelinated fibers in test and control populations, we did observe a trend indicating a reduction in the numbers of myelinated fibers. The mean numbers of myelin lamellae, from an average of all myelinated axons, were not different in control and test population. However, regression analysis of axon sizes by numbers of myelin lamellae revealed significant differences from the normal in 21-day-old undernourished rats. For callosal axons of any size, there were too few myelin lamellae in the undernourished rats. A partial recovery was observed in relatively small fibers by 35 days of age, but no recovery was observed in larger sized fibers. Comparison of the frequency distribution of axon circumferences of myelinated fibers revealed an increase in average axonal caliber. Computation shows that although mean numbers of lamellae were not altered by undernourishment, the axons themselves are increased in size by about 10%. This unexpected result indicates that the relationship normally governing the numbers of myelin lamellae is altered by postnatal nutritional deprivation, and that the relatively larger axon calibers do not produce in the ensheating oligodendroglia any compensatory increase in the layers of myelin.