Evidence supporting a rote for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia -: Young Investigator Award
Evidence supporting a rote for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia -: Young Investigator Award
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DOI：
10.1016/j.ajog.2004.03.043
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发表时间：
2004-06-01
影响因子：
9.8
通讯作者：
Edwin, S
中科院分区：
文献类型：
--
作者：
Chaiworapongsa, T;Romero, R;Edwin, S
目的：可溶性血管内皮生长因子受体I（SVEGFR-1），它拮抗VEGF功能，与先兆子痫的病理生理有关。这项研究的目的是确定先兆子痫与SVEGFR-1血浆浓度的变化是否相关，如果是这样，这种变化是否与疾病的严重程度相关。进行以确定从正常孕妇（n = 61）和先兆子痫患者（n = 6 1）的血浆中SVEGFR-1的浓度。通过酶联免疫测定确定SVEGFR-1的血浆浓度。分子：前启示识别的SVEGFR-1的中位血浆浓度高于正常妊娠（P <.001）。 SVEGFR-1的中位血浆浓度在早期（小于或等于34周）中高于晚期（> 34周）的前启示性（p = .005），而在严重性的前宾夕法尼亚（P = .005）中高于轻度前丙型诊所（p） = .002）。在正常妊娠中，SVEGFR-1的血浆浓度与胎龄之间存在相关性（r = 0.5; p <.001）。相比之下，先兆子痫开始时SVEGFR-1的血浆浓度与妊娠年龄之间存在负相关性（r = -0.5; p <.001）。结论：con键：preclampsia与血浆SVEGFR-1浓度的增加有关。 SVEGFR-1浓度的升高与疾病的严重程度相关。这些观察结果表明，VEGF及其可溶性受体参与了先兆子痫的病理生理学。 （c）2004 Elsevier Inc.保留所有权利。
Objective: Soluble vascular endothelial growth factor receptor I (sVEGFR-1), which antagonizes VEGF functions, has been implicated in the pathophysiology of preeclampsia. The purpose of this study was to determine whether preeclampsia is associated with a change in the plasma concentration of sVEGFR-1, and, if so, whether such a change is correlated with the severity of the disease.Methods: A cross-sectional study was conducted to determine the concentrations of sVEGFR-1 in plasma obtained from normal pregnant women (n = 61) and patients with preeclampsia (n = 6 1). Plasma concentrations of sVEGFR-1 were determined by enzyme-linked immunoassay.Results: Preeclampsia had a higher median plasma concentration of sVEGFR-1 than normal pregnancy (P < .001). The median plasma concentration of sVEGFR-1 was higher in early-onset (less than or equal to 34 weeks) than late-onset ( > 34 weeks) preeclampsia (P = .005), and higher in severe than in mild preeclampsia (P = .002). In normal pregnancy, there was a correlation between plasma concentration of sVEGFR-1 and gestational age (r = 0.5; P < .001). In contrast, there was a negative correlation between plasma concentration of sVEGFR-1 and gestational age at the onset of preeclampsia (r = -0.5; P < .001).Conclusion: Preeclampsia is associated with an increased plasma sVEGFR-1 concentration. The elevation of sVEGFR-1 concentration is correlated with the severity of the disease. These observations suggest the participation of VEGF and its soluble receptor in the pathophysiology of preeclampsia. (C) 2004 Elsevier Inc. All rights reserved.