Biomimetic particles as therapeutics.
Biomimetic particles as therapeutics.
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DOI：
10.1016/j.tibtech.2015.07.001
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发表时间：
2015-09
影响因子：
17.3
通讯作者：
Green JJ
中科院分区：
文献类型：
--
作者：
Meyer RA;Sunshine JC;Green JJ
近年来，在基于新型纳米颗粒和微粒的治疗剂的开发方面取得了重大进展。一个新兴的范例是将仿生特征并入这些合成治疗构建体中，以使它们能够更好地与生物系统相互作用。通过控制大小、形状和材料一致性，已经产生了更好地模拟天然细胞和病毒的颗粒核心。此外，通过生物启发的人工细胞膜和天然衍生的细胞膜的整合，在颗粒的仿生表面功能化方面已经取得了显著进展。仿生技术使治疗颗粒具有增加的效力以有益于人类健康。
In recent years, there have been major advances in the development of novel nanoparticle and microparticle-based therapeutics. An emerging paradigm is the incorporation of biomimetic features into these synthetic therapeutic constructs to enable them to better interface with biological systems. Through the control of size, shape, and material consistency, particle cores have been generated that better mimic natural cells and viruses. In addition, there have been significant advances in biomimetic surface functionalization of particles through the integration of bio-inspired artificial cell membranes and naturally derived cell membranes. Biomimetic technologies enable therapeutic particles to have increased potency to benefit human health.